SCFFBXO28 介导的 FBXO28 自泛素化促进其降解。
关键词: Cullin-Ring E3 ubiquitin ligase FBXO28 Neddylation SCF Self-ubiquitination
Mesh : Antineoplastic Agents / pharmacology Cell Line Chromatography, Liquid Cullin Proteins / metabolism Cyclopentanes / pharmacology Cysteine Proteinase Inhibitors / pharmacology Enzyme Inhibitors / pharmacology F-Box Proteins / metabolism Humans Leupeptins / pharmacology Proteasome Endopeptidase Complex / drug effects metabolism Proteome / drug effects metabolism Pyrimidines / pharmacology SKP Cullin F-Box Protein Ligases / genetics metabolism Signal Transduction / drug effects genetics Tandem Mass Spectrometry Transcriptional Activation Ubiquitination / drug effects
来 源:
DOI:10.1016/j.cellsig.2019.109440
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