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Abstract：
Debate exists for the optimal tool to select embryos for transfer in assisted reproductive technology (ART). Time-lapse monitoring (TLM) is a noninvasive tool suggested where each embryo can be captured every 5-20 min. Given the inconsistency in the existing studies, we conducted this meta-analysis of RCTs to summarize the evidence available concerning the predictive ability of morphokinetics compared with the routine assessment of embryo development in ART.
The primary databases MEDLINE, EMBASE, Cochrane, NHS, WHO, and Other Non-Indexed Citations were consulted for RCTs that have been published until November 2018, with no language restriction.
Our review includes 6 RCTs (n = 2057 patients). The data showed an improvement (~ 9%) in live birth TLM (OR 1.43; 95% CI 1.10-1.85; P = 0.007), with low-quality evidence. There was no evidence of a significant difference between both groups concerning ongoing pregnancy, clinical pregnancy and implantation rates. The data further showed that morphokinetics is associated with decreased early pregnancy loss rate. These estimates must be interpreted with caution owing to the statistical and clinical heterogeneities and the consequent difficulty in drawing any meaningful conclusion.
The primary databases MEDLINE, EMBASE, Cochrane, NHS, WHO, and Other Non-Indexed Citations were consulted for RCTs that have been published until November 2018, with no language restriction.
Our review includes 6 RCTs (n = 2057 patients). The data showed an improvement (~ 9%) in live birth TLM (OR 1.43; 95% CI 1.10-1.85; P = 0.007), with low-quality evidence. There was no evidence of a significant difference between both groups concerning ongoing pregnancy, clinical pregnancy and implantation rates. The data further showed that morphokinetics is associated with decreased early pregnancy loss rate. These estimates must be interpreted with caution owing to the statistical and clinical heterogeneities and the consequent difficulty in drawing any meaningful conclusion.
摘要：
在辅助生殖技术（ART）中选择胚胎移植的最佳工具存在争议。延时监测（TLM）是一种非侵入性工具，建议每5-20分钟捕获每个胚胎。鉴于现有研究的不一致，我们对RCT进行了荟萃分析,以总结与ART中胚胎发育常规评估相比,形态动力学预测能力的现有证据.
主数据库MEDLINE,EMBASE,科克伦,NHS,WHO,对于截至2018年11月发布的RCT,我们咨询了其他非索引引文,没有语言限制.
我们的综述包括6项RCT（n=2057例患者）。数据显示活产TLM改善（约9％）（OR1.43；95％CI1.10-1.85；P=0.007），低质量的证据。没有证据表明两组之间在持续怀孕方面存在显着差异，临床妊娠和植入率。数据进一步表明，形态动力学与早期妊娠损失率降低有关。由于统计和临床异质性以及由此得出任何有意义的结论的困难，必须谨慎解释这些估计。
主数据库MEDLINE,EMBASE,科克伦,NHS,WHO,对于截至2018年11月发布的RCT,我们咨询了其他非索引引文,没有语言限制.
我们的综述包括6项RCT（n=2057例患者）。数据显示活产TLM改善（约9％）（OR1.43；95％CI1.10-1.85；P=0.007），低质量的证据。没有证据表明两组之间在持续怀孕方面存在显着差异，临床妊娠和植入率。数据进一步表明，形态动力学与早期妊娠损失率降低有关。由于统计和临床异质性以及由此得出任何有意义的结论的困难，必须谨慎解释这些估计。
