关键词: Disseminated infection Emergomyces HIV

Mesh : Acquired Immunodeficiency Syndrome / microbiology Actins / genetics Adult Amphotericin B / therapeutic use Antifungal Agents / therapeutic use DNA, Intergenic / genetics DNA, Ribosomal / genetics Deoxycholic Acid / therapeutic use Drug Combinations Female Humans India Inteins / genetics Itraconazole / therapeutic use Mycoses / diagnosis genetics microbiology Onygenales Tubulin / genetics

来  源:   DOI:10.1007/s11046-019-00387-y   PDF(Sci-hub)

Abstract:
We report here a case of disseminated Emergomyces pasteurianus infection from India in a patient with AIDS. The patient presented with weight loss, dyspnoea and multiple non-tender skin lesions over face, neck and chest over 3 months. The case was diagnosed by microscopy, histopathology of sample and isolation of fungus from skin lesion, breast nodule, bone marrow and sputum. The identification of the isolates was confirmed by sequencing internal transcribed spacer region of rDNA, beta-tubulin, actin and intein PRP8. The patient responded well to intravenous amphotericin B deoxycholate followed by itraconazole therapy.
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