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Abstract：
BACKGROUND: There is no consensus in the literature regarding risk factors associated with recurrence of uterine leiomyomas. In this study, we evaluated the factors that affect the recurrence of uterine leiomyomas in women who underwent laparotomic or endoscopic myomectomy.
METHODS: This retrospective study included 378 patients that underwent myomectomy. Patient follow-up ranged from two to eight years, and they were classified according to the recurrence of myoma uteri. Age, gravidity, parity, presenting complaints, prior surgery, comorbidity, smoking status, intraoperative and postoperative features, and Ca 125 levels were obtained from the hospital records and patient files.
RESULTS: Recurrence was detected in 67 women (17.72 %). No statistically significant differences were observed in the demographic data and past obstetric history between the recurrent and non-recurrent groups. The number of myomas was higher in the recurrence group as compared to the non-recurrence group [2 (range: 1-41) vs 1 (1-19), respectively, p =0.022]. Pregnancy rates were statistically higher in the recurrence group as compared to the non- recurrence group (17.9 % vs 7.1 %, respectively, p =0.005). Pregnancy after myomectomy increased the risk of recurrence by 2.8-fold (odds ratio: 2.87; 95 % confidence interval: 1.34-6.13). No significant differences were observed between the two groups regarding the surgical route, fibroid size, uterine location, and position of the myomas in the uterus.
CONCLUSIONS: Women who had more than two myomas should be informed of the possibility of recurrent myoma uteri. Additionally, pregnancy in women who previously had a myomectomy was found to be a risk factor for recurrence of the uterine myoma. HIPPOKRATIA 2018, 22(3): 122-126.
METHODS: This retrospective study included 378 patients that underwent myomectomy. Patient follow-up ranged from two to eight years, and they were classified according to the recurrence of myoma uteri. Age, gravidity, parity, presenting complaints, prior surgery, comorbidity, smoking status, intraoperative and postoperative features, and Ca 125 levels were obtained from the hospital records and patient files.
RESULTS: Recurrence was detected in 67 women (17.72 %). No statistically significant differences were observed in the demographic data and past obstetric history between the recurrent and non-recurrent groups. The number of myomas was higher in the recurrence group as compared to the non-recurrence group [2 (range: 1-41) vs 1 (1-19), respectively, p =0.022]. Pregnancy rates were statistically higher in the recurrence group as compared to the non- recurrence group (17.9 % vs 7.1 %, respectively, p =0.005). Pregnancy after myomectomy increased the risk of recurrence by 2.8-fold (odds ratio: 2.87; 95 % confidence interval: 1.34-6.13). No significant differences were observed between the two groups regarding the surgical route, fibroid size, uterine location, and position of the myomas in the uterus.
CONCLUSIONS: Women who had more than two myomas should be informed of the possibility of recurrent myoma uteri. Additionally, pregnancy in women who previously had a myomectomy was found to be a risk factor for recurrence of the uterine myoma. HIPPOKRATIA 2018, 22(3): 122-126.
摘要：
背景：关于与子宫平滑肌瘤复发相关的危险因素，文献尚无共识。在这项研究中,在接受腹腔镜或内镜子宫肌瘤切除术的女性中,我们评估了影响子宫肌瘤复发的因素.
方法：这项回顾性研究包括378例接受子宫肌瘤切除术的患者。患者随访时间为2至8年,根据子宫肌瘤的复发情况进行分类。年龄,妊娠,奇偶校验，提出投诉，之前的手术,合并症，吸烟状况,术中和术后特征，从医院记录和患者档案中获得Ca125水平。
结果：在67名女性中检测到复发（17.72%）。在复发和非复发组之间，人口统计学数据和既往产科史没有观察到统计学上的显着差异。复发组肌瘤数量高于未复发组[2（范围：1-41）vs1（1-19），分别,p=0.022]。复发组的妊娠率高于未复发组（17.9%vs7.1%，分别,p=0.005)。子宫肌瘤切除术后妊娠的复发风险增加2.8倍（比值比：2.87；95％置信区间：1.34-6.13）。两组在手术途径方面没有观察到显著差异。纤维瘤大小,子宫位置,子宫肌瘤的位置.
结论：患有两个以上肌瘤的妇女应被告知子宫肌瘤复发的可能性。此外,在曾经做过子宫肌瘤切除术的女性中,妊娠是子宫肌瘤复发的危险因素.HIPPOKRATIA2018,22(3):122-126.
方法：这项回顾性研究包括378例接受子宫肌瘤切除术的患者。患者随访时间为2至8年,根据子宫肌瘤的复发情况进行分类。年龄,妊娠,奇偶校验，提出投诉，之前的手术,合并症，吸烟状况,术中和术后特征，从医院记录和患者档案中获得Ca125水平。
结果：在67名女性中检测到复发（17.72%）。在复发和非复发组之间，人口统计学数据和既往产科史没有观察到统计学上的显着差异。复发组肌瘤数量高于未复发组[2（范围：1-41）vs1（1-19），分别,p=0.022]。复发组的妊娠率高于未复发组（17.9%vs7.1%，分别,p=0.005)。子宫肌瘤切除术后妊娠的复发风险增加2.8倍（比值比：2.87；95％置信区间：1.34-6.13）。两组在手术途径方面没有观察到显著差异。纤维瘤大小,子宫位置,子宫肌瘤的位置.
结论：患有两个以上肌瘤的妇女应被告知子宫肌瘤复发的可能性。此外,在曾经做过子宫肌瘤切除术的女性中,妊娠是子宫肌瘤复发的危险因素.HIPPOKRATIA2018,22(3):122-126.
