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Abstract：
Pregnancy has a dual effect on the risk of breast cancer. On one hand, pregnancy at a young age is known to be protective. However, pregnancy is also associated with a transient increased risk of breast cancer. For women that have children after the age of 30, the risk remains higher than women who never had children for decades. Involution of the breast has been identified as a window of mammary development associated with the adverse effect of pregnancy. In this review, we summarize the current understanding of the role of involution and describe the role of collagen in this setting. We also discuss the role of a collagen-dependent protease, pappalysin-1, in postpartum breast cancer and its role in activating both insulin-like growth factor signaling and discoidin domain collagen receptor 2, DDR2. Together, these novel advances in our understanding of postpartum breast cancer open the way to targeted therapies against this aggressive breast cancer sub-type.
摘要：
怀孕对乳腺癌的风险有双重影响。一方面,众所周知，年轻时怀孕是有保护作用的。然而,怀孕也与乳腺癌风险的短暂增加有关。对于30岁以后有孩子的女性来说，风险仍然高于几十年没有孩子的女性。乳房的卷积已被确定为与妊娠的不利影响相关的乳房发育的窗口。在这次审查中,我们总结了目前对复旧作用的理解，并描述了胶原蛋白在这种情况下的作用。我们还讨论了胶原蛋白依赖性蛋白酶的作用，pappalysin-1在产后乳腺癌中的作用及其在激活胰岛素样生长因子信号和盘状结构域胶原受体2，DDR2中的作用。一起,我们对产后乳腺癌认识的这些新进展为针对这种侵袭性乳腺癌亚型的靶向治疗开辟了道路.
