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Abstract：
Amplified innate leukocytes (neutrophils and monocytes/macrophages) are associated with advanced ischemic and non-ischemic heart failure (HF). Intensified neutrophilic leukocytosis (neutrophilia) and sustained activation of neutrophils is the predominant factor that determines over activated inflammation in acute HF and the outcome of long-term chronic HF. After heart attack, the first wave of innate responsive and short-lived neutrophils is essential for the initiation of inflammation, resolution of inflammation, and cardiac repair, however uncontrolled and long-term activation of neutrophils leads to collateral damage of myocardium. In the presented review, we highlighted the interactive and integrative role of neutrophil phenotypes in cellular and molecular events of ischemic HF. In addition, we discussed the current, nonimmune, immune, and novel paradigms of neutrophils in HF associated with differential factors with a specific interest in non-resolving inflammation and resolution physiology.
摘要：
扩增的先天白细胞(嗜中性粒细胞和单核细胞/巨噬细胞)与晚期缺血性和非缺血性心力衰竭(HF)相关。嗜中性粒细胞增多症（嗜中性粒细胞增多症）和嗜中性粒细胞持续活化是决定急性HF过度活化炎症和长期慢性HF结局的主要因素。心脏病发作后,第一波先天反应性和短寿命的中性粒细胞对于炎症的启动是必不可少的，炎症的消退，和心脏修复，然而中性粒细胞的不受控制和长期激活会导致心肌的附带损害。在提交的审查中，我们强调了中性粒细胞表型在缺血性HF细胞和分子事件中的相互作用和整合作用.此外,我们讨论了当前，非免疫,免疫，以及与不同因素相关的HF中性粒细胞的新范例，对非解决炎症和解决生理学有特殊兴趣。
