ADP - 核糖基化因子的 N 末端与 GTP 酶激活蛋白 ASAP1 的 PH 结构域的相互作用需要磷脂酰肌醇 4, 5 - 双磷酸。
关键词: ADP ribosylation factor (ARF) ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) GTPase-activating protein (GAP) actin remodeling allosteric regulation cell signaling integrin adhesion phosphatidylinositol 4,5-bisphosphate (PIP2) pleckstrin homology domain protein–protein interaction
Mesh : ADP-Ribosylation Factor 1 / chemistry genetics ADP-Ribosylation Factors / chemistry genetics Actins / chemistry genetics Adaptor Proteins, Signal Transducing / chemistry genetics GTPase-Activating Proteins / chemistry genetics Humans Neoplasms / genetics Phosphatidylinositol 4,5-Diphosphate / chemistry genetics Pleckstrin Homology Domains / genetics Point Mutation / genetics Protein Binding / genetics
来 源:
DOI:10.1074/jbc.RA119.009269
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