Retroperitoneal extraosseous peripheral primitive neuroectodermal tumor in a Formosan serow: case report and literature review.

• 影响指数: 1.569
• 发表时间: Nov 2019
• 来源期刊: J Vet Diagn Invest
• DOI: 10.1177/1040638719879198
• PMID: 31585511
• 文章类型: Case Reports
• 中科院分区: Q2
• 作者列表: Hsieh YH,Hsu YH,Lien CY,Liu CH,Li WT

关键词: Formosan serow; Friend leukemia integration 1; peripheral primitive neuroectodermal tumor

Mesh: Animals; Biomarkers, Tumor / metabolism; Fatal Outcome; Female; Neuroectodermal Tumors, Primitive, Peripheral / diagnosis pathology; Proto-Oncogene Protein c-fli-1 / metabolism; Ruminants

Abstract

A 10-y-old female captive Formosan serow (Capricornis swinhoei) was inactive and was azotemic. An autopsy was performed following her death, and multiple irregularly shaped, white-to-gray masses of 0.5-2 cm diameter were noted on both ureters, the left adrenal gland, urinary bladder, and uterus. Microscopically, organs were effaced by a poorly demarcated, highly infiltrative neoplasm, composed of neoplastic round cells arranged in islands, sheets, or nests with occasional rosette formation. The neoplastic cells were small: ≤2 red blood cell (≤ 15 μm) diameter. The neoplastic cells were positive for CD56, CK, FLI-1, and NSE, but negative for desmin, GFAP, melan A, NF, PAX-8, S100, synaptophysin, and vimentin. Therefore, the diagnosis of retroperitoneal extraosseous peripheral primitive neuroectodermal tumor (pPNET) was made. pPNET with FLI-1 expression has not been reported previously in animals, to our knowledge.