关键词: Case Reports Pediatrics Treatment

Mesh : Adrenergic beta-2 Receptor Agonists / adverse effects therapeutic use Albuterol / adverse effects therapeutic use Asthma / drug therapy Bronchodilator Agents / administration & dosage adverse effects therapeutic use Child Female Humans Ipratropium / therapeutic use Levalbuterol / adverse effects therapeutic use

来  源:   DOI:10.1080/02770903.2019.1668009   PDF(Sci-hub)

Abstract:
Introduction: Asthma is one of the most common airway diseases that nearly all pediatricians will encounter in their clinical practice. Using spirometry to compare a patient\'s forced expiratory volume in one second (FEV1) both pre- and post-bronchodilator administration is the ideal way to document a paradoxical bronchodilator response.Case Study: Here, we present a patient who experienced paradoxical responses to short acting beta-2 agonists (SABAs; albuterol and levalbuterol).Results: This patient responded to an anti-cholinergic agent (ipratropium bromide) with both subjective as well as objective response.Conclusion: This case highlights the need to include paradoxical response to SABAs in the differential of a patient with poorly controlled asthma. It also provides an example of successful treatment of a pediatric patient with a class of medications previously reserved for adults with chronic obstructive pulmonary disease.
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