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Abstract：
Sale of electronic cigarette (e-cigarette) products has exponentially increased in the past decade, which raise concerns about its safety. This updated review provides the available toxicology profile of e-cigarettes, summarizing evidence from in vitro and in vivo studies. Data regarding which components in e-liquids exhibit potential toxicities are inconsistent. Some studies have reported that nicotine plays a significant role in inducing adverse outcomes and that solvents alone do not induce any adverse effects. However, other studies have suggested that nicotine is not associated with any adverse outcomes, whereas solvents and flavorings are the key components to elicit considerable deleterious effects on cells or animals. In addition, most of the studies that have compared the toxicity of e-cigarettes with tobacco cigarettes have suggested that e-cigarettes are less toxic than tobacco cigarettes. Nevertheless, scientific evidence regarding the toxicity profile of e-cigarette is insufficient owing to the lack of a standardized research approach. In the future, scientific toxicology data derived from standardized testing protocols including nicotine, ingredients analysis, the various e-cigarette devices made from different materials are urgently needed for thorough toxicology assessment. This review aims to update the toxicity profiles, identify knowledge gaps, and outline future directions for e-cigarettes research, which would greatly benefit public health professionals.
摘要：
电子烟（电子烟）产品的销售在过去十年中呈指数增长，这引起了人们对其安全性的担忧。此更新的评论提供了电子烟的可用毒理学概况，总结体外和体内研究的证据。关于电子液体中哪些成分表现出潜在毒性的数据不一致。一些研究报告说，尼古丁在诱发不良后果中起着重要作用，单独的溶剂不会引起任何不良反应。然而,其他研究表明，尼古丁与任何不良后果无关，而溶剂和调味剂是对细胞或动物引起相当大的有害影响的关键成分。此外,大多数将电子烟的毒性与烟草烟进行比较的研究表明，电子烟的毒性低于烟草烟。然而，由于缺乏标准化的研究方法，有关电子烟毒性特征的科学证据不足。在未来,来自包括尼古丁在内的标准化测试协议的科学毒理学数据，成分分析,由不同材料制成的各种电子烟设备迫切需要进行全面的毒理学评估。这篇综述旨在更新毒性概况，确定知识差距，并概述了电子烟研究的未来方向，这将大大有利于公共卫生专业人员。
