METHODS: Fifty control donors and fifty acute myeloid leukemia patients were enrolled in this research. The levels of WWOX gene in all participants were detected by RT-qPCR.
RESULTS: Levels of WWOX gene in the AML group were significantly lower as compared to the control group (0.27205 ± 1.19812 vs. 10.501 ± 9.0338, respectively, p < 0.001**).
CONCLUSIONS: Decreased expression of WWOX gene ran parallel with acute myeloid leukemia regression.