PDF(Pubmed)
Abstract：
UNASSIGNED: Calmodulin (CaM) is a multifunctional intermediate messenger protein that plays important role in cell motility, proliferation, and apoptosis. Therefore, it is thought to be involved in various ways in the apoptotic processes which are implicated in the pathogenesis of lichen planus.
UNASSIGNED: The aim of this study was to evaluate the immunohistochemical expression of CaM in lichen planus lesions in comparison to normal control skin to throw light on its possible role in disease pathogenesis.
UNASSIGNED: This case-control study was conducted on 50 patients with lichen planus, in addition to 20 age- and sex-matched healthy individuals. Skin biopsy specimens were taken from lesional skin of lichen planus patients as well as normal skin of controls. All were examined for immunohistochemical expression of CaM antibody.
UNASSIGNED: There was statistically significant increase of the immunohistochemical expression of CaM in lesional skin of lichen planus patients compared with normal skin of controls (Chi-square test, P < 0.001). No significant correlation could be detected between CaM expression in lesional skin and the studied clinical parameters of lichen planus patients.
UNASSIGNED: Tha main limitation of this study is its small sample size.
UNASSIGNED: CaM is upregulated in cutaneous lichen planus lesions suggesting a possible role in disease pathogenesis. Targeting CaM is expected to be a novel strategy for treatment of lichen planus.
UNASSIGNED: The aim of this study was to evaluate the immunohistochemical expression of CaM in lichen planus lesions in comparison to normal control skin to throw light on its possible role in disease pathogenesis.
UNASSIGNED: This case-control study was conducted on 50 patients with lichen planus, in addition to 20 age- and sex-matched healthy individuals. Skin biopsy specimens were taken from lesional skin of lichen planus patients as well as normal skin of controls. All were examined for immunohistochemical expression of CaM antibody.
UNASSIGNED: There was statistically significant increase of the immunohistochemical expression of CaM in lesional skin of lichen planus patients compared with normal skin of controls (Chi-square test, P < 0.001). No significant correlation could be detected between CaM expression in lesional skin and the studied clinical parameters of lichen planus patients.
UNASSIGNED: Tha main limitation of this study is its small sample size.
UNASSIGNED: CaM is upregulated in cutaneous lichen planus lesions suggesting a possible role in disease pathogenesis. Targeting CaM is expected to be a novel strategy for treatment of lichen planus.
摘要：
■钙调蛋白（CaM）是一种多功能的中间信使蛋白，在细胞运动中起重要作用，扩散,和凋亡。因此,它被认为以各种方式参与凋亡过程，这些过程与扁平苔藓的发病机理有关。
■这项研究的目的是与正常对照皮肤相比，评估CaM在扁平苔藓病变中的免疫组织化学表达，以阐明其在疾病发病机理中的可能作用。
■这项病例对照研究是对50例扁平苔藓患者进行的，除了20个年龄和性别匹配的健康个体。皮肤活检标本取自扁平苔藓患者的病灶皮肤以及对照组的正常皮肤。检测CaM抗体的免疫组织化学表达。
■与对照组的正常皮肤相比，扁平苔藓患者病变皮肤中CaM的免疫组织化学表达有统计学意义（卡方检验，P<0.001)。皮损中CaM的表达与扁平苔藓患者的临床参数之间没有显着相关性。
■本研究的主要限制是样本量小。
■CaM在皮肤扁平苔藓病变中上调，提示在疾病发病机理中可能发挥作用。靶向CaM有望成为治疗扁平苔藓的新策略。
■这项研究的目的是与正常对照皮肤相比，评估CaM在扁平苔藓病变中的免疫组织化学表达，以阐明其在疾病发病机理中的可能作用。
■这项病例对照研究是对50例扁平苔藓患者进行的，除了20个年龄和性别匹配的健康个体。皮肤活检标本取自扁平苔藓患者的病灶皮肤以及对照组的正常皮肤。检测CaM抗体的免疫组织化学表达。
■与对照组的正常皮肤相比，扁平苔藓患者病变皮肤中CaM的免疫组织化学表达有统计学意义（卡方检验，P<0.001)。皮损中CaM的表达与扁平苔藓患者的临床参数之间没有显着相关性。
■本研究的主要限制是样本量小。
■CaM在皮肤扁平苔藓病变中上调，提示在疾病发病机理中可能发挥作用。靶向CaM有望成为治疗扁平苔藓的新策略。
