Mesh : Amphotericin B / administration & dosage therapeutic use Anti-Bacterial Agents / administration & dosage therapeutic use Antifungal Agents / therapeutic use Brazil / epidemiology Humans Liver Transplantation / adverse effects Male Middle Aged Paracoccidioides Paracoccidioidomycosis / diagnosis drug therapy epidemiology Transplant Recipients Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage therapeutic use

来  源:   DOI:10.4269/ajtmh.18-1008   PDF(Pubmed)

Abstract:
Paracoccidioidomycosis (PCM) is an endemic systemic mycosis that is of great importance in Latin America. Its occurrence in solid organ transplantation (SOT) is rare, but with high mortality rate. In this report, we describe a case of PCM in a liver transplant recipient 19 months after transplantation. The patient presented with multiple skin abscesses, arthritis, osteolytic lesions, and pulmonary and adrenal involvement. Despite the presence of disseminated disease and the patient\'s immunosuppressed condition, the patient responded well to prolonged antifungal treatment with no sequelae, thus suggesting that early diagnosis and correct treatment may lead to favorable outcomes in SOT recipients with PCM.
摘要:
副角菌病(PCM)是一种地方性全身性真菌病,在拉丁美洲非常重要。它在实体器官移植(SOT)中的发生很少,但是死亡率很高。在这份报告中,我们描述了一例肝移植受者在移植后19个月感染PCM的病例.患者出现多个皮肤脓肿,关节炎,溶骨性病变,肺和肾上腺受累。尽管存在播散性疾病和患者的免疫抑制状况,患者对长期抗真菌治疗反应良好,没有后遗症,因此表明早期诊断和正确治疗可能会导致患有PCM的SOT接受者的良好结局。
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