Updated mechanisms underlying sickle cell disease-associated pain.

更新了镰状细胞疾病相关疼痛的潜在机制。

• 影响指数: 3.197
• 发表时间: 11 2019 1
• 来源期刊: Neurosci Lett
• DOI: 10.1016/j.neulet.2019.134471
• PMID: 31505241
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 生物
• 作者列表: Du S,Lin C,Tao YX

关键词: Cannabinoid receptors; Endothelin type A receptor; Endothelin-1; Pain; Sickle cell disease; TRPV1

Mesh: Anemia, Sickle Cell / complications metabolism physiopathology; Humans; Pain / etiology metabolism physiopathology; Quality of Life; Receptor, Endothelin A / genetics metabolism; Receptors, Cannabinoid / genetics metabolism; TRPV Cation Channels / genetics metabolism

Abstract

Sickle cell disease (SCD) is one of the most common severe genetic diseases around the world. A majority of SCD patients experience intense pain, leading to hospitalization, and poor quality of life. Opioids form the bedrock of pain management, but their long-term use is associated with severe side effects including hyperalgesia, tolerance and addiction. Recently, excellent research has shown some new potential mechanisms that underlie SCD-associated pain. This review focused on how transient receptor potential vanilloid 1, endothelin-1/endothelin type A receptor, and cannabinoid receptors contributed to the pathophysiology of SCD-associated pain. Understanding these mechanisms may open a new avenue in managing SCD-associated pain and improving quality of life for SCD patients.

摘要

镰状细胞病（SCD）是世界上最常见的严重遗传疾病之一。大多数SCD患者会经历剧烈的疼痛，导致住院，和生活质量差。阿片类药物是疼痛管理的基石，但是它们的长期使用会带来严重的副作用，包括痛觉过敏，宽容和成瘾。最近,优秀的研究显示了一些新的潜在机制,这些机制是SCD相关疼痛的基础.本文综述了瞬时受体电位香草素1、内皮素-1/内皮素A和大麻素受体有助于SCD相关疼痛的病理生理学。了解这些机制可能为治疗SCD相关疼痛和改善SCD患者的生活质量开辟新的途径。