Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension.

• 影响指数: 3.216
• 发表时间: 08 2020
• 来源期刊: J Cardiovasc Transl Res
• DOI: 10.1007/s12265-019-09910-4
• PMID: 31463701
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Fudim M,Blumer VL,Lopes RD,Rossignol P,Feldschuh M,Miller WL,Sobotka PA

关键词: Blood volume analysis; Gender; Hypertension; Race

Mesh: Blood Pressure; Blood Volume; Blood Volume Determination; Chronic Disease; Erythrocyte Volume; Female; Humans; Hypertension / diagnosis physiopathology; Male; Middle Aged; Plasma Volume; Predictive Value of Tests; Radioisotope Dilution Technique; Retrospective Studies; Serum Albumin, Radio-Iodinated / administration & dosage

Abstract

Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from - 23 to + 28% for TBV, - 22 to + 36% for PV and - 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = - 0.03; PV and SBP, r = - 0.12; RBV and SBP, r = - 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.