PDF(Pubmed)
Abstract：
UNASSIGNED: Odontogenic cysts are distinct entities and quite a common occurrence in the jaw bones. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Cytokeratins are integral components in tooth development and are expressed across the odontogenic tissues in physiological and pathological states.
UNASSIGNED: To elucidate the role of cytokeratin-7 in the pathogenesis of odontogenic cysts by immunohistochemistry.
UNASSIGNED: Cytokeratin-7 (CK-7) was assessed in 39 cases of odontogenic lesions retrieved from the archival files which included 15 cases of dentigerous cysts (DC), 12 cases of odontogenic keratocysts (OKC) and 12 cases of radicular cysts (RC) and also 8 cases of control specimens.
UNASSIGNED: Results obtained were statistically analyzed using chi-square test to assess the association between different odontogenic cysts used in this study and Cytokeration-7 staining. The difference was considered to be of statistical significance if the p value was ≤ 0.05.
UNASSIGNED: CK7 expression was maximum in dentigerous cycts (66.66%) followed by radicular cysts (41.66%) and odontogenic keratocysts (16.6%). On evaluation of staining and expression pattern, highest positivity is shown in dentigerous cysts and the positivity is seen in suprabasal (60%) and superficial layers (40%) whereas radicular cysts and odontogenic keratocysts showed positivity in superficial and spinous layers.
UNASSIGNED: Cytokeratin-7 expression correlates with the degree of differentiation of the epithelium. So the cysts with a well-differentiated epithelium (RC and DC) express CK-7, while the cysts with a less well-differentiated epithelium (OKC) show slight positivity. Thus it can be useful to differentiate OKC from DC and RC.
UNASSIGNED: To elucidate the role of cytokeratin-7 in the pathogenesis of odontogenic cysts by immunohistochemistry.
UNASSIGNED: Cytokeratin-7 (CK-7) was assessed in 39 cases of odontogenic lesions retrieved from the archival files which included 15 cases of dentigerous cysts (DC), 12 cases of odontogenic keratocysts (OKC) and 12 cases of radicular cysts (RC) and also 8 cases of control specimens.
UNASSIGNED: Results obtained were statistically analyzed using chi-square test to assess the association between different odontogenic cysts used in this study and Cytokeration-7 staining. The difference was considered to be of statistical significance if the p value was ≤ 0.05.
UNASSIGNED: CK7 expression was maximum in dentigerous cycts (66.66%) followed by radicular cysts (41.66%) and odontogenic keratocysts (16.6%). On evaluation of staining and expression pattern, highest positivity is shown in dentigerous cysts and the positivity is seen in suprabasal (60%) and superficial layers (40%) whereas radicular cysts and odontogenic keratocysts showed positivity in superficial and spinous layers.
UNASSIGNED: Cytokeratin-7 expression correlates with the degree of differentiation of the epithelium. So the cysts with a well-differentiated epithelium (RC and DC) express CK-7, while the cysts with a less well-differentiated epithelium (OKC) show slight positivity. Thus it can be useful to differentiate OKC from DC and RC.
摘要：
■牙源性囊肿是不同的实体，在颌骨中很常见。这些是由相同的牙源性器官引起的个体病变，但发病机理不同。细胞角蛋白是牙齿发育中不可或缺的组成部分，并在生理和病理状态下在牙源性组织中表达。
■通过免疫组织化学阐明细胞角蛋白7在牙源性囊肿发病机制中的作用。
■在从档案中检索到的39例牙源性病变中评估了细胞角蛋白-7（CK-7），其中包括15例牙源性囊肿（DC），牙源性角化囊肿（OKC）12例，神经根囊肿（RC）12例，对照标本8例。
■使用卡方检验对获得的结果进行统计分析，以评估本研究中使用的不同牙源性囊肿与Cytokeration-7染色之间的关联。如果p值≤0.05，则认为差异具有统计学意义。
■CK7在牙源性膀胱中表达最高（66.66％），其次是神经根囊肿（41.66％）和牙源性角化囊肿（16.6％）。关于染色和表达模式的评估，在牙质囊肿中显示出最高的阳性，在浅层（60％）和浅层（40％）中可见阳性，而在浅层和棘层中显示出阳性。
■细胞角蛋白-7的表达与上皮的分化程度相关。因此,具有高分化上皮(RC和DC)的囊肿表达CK-7,而具有低分化上皮(OKC)的囊肿显示轻微阳性。因此,将OKC与DC和RC区分开可能是有用的。
■通过免疫组织化学阐明细胞角蛋白7在牙源性囊肿发病机制中的作用。
■在从档案中检索到的39例牙源性病变中评估了细胞角蛋白-7（CK-7），其中包括15例牙源性囊肿（DC），牙源性角化囊肿（OKC）12例，神经根囊肿（RC）12例，对照标本8例。
■使用卡方检验对获得的结果进行统计分析，以评估本研究中使用的不同牙源性囊肿与Cytokeration-7染色之间的关联。如果p值≤0.05，则认为差异具有统计学意义。
■CK7在牙源性膀胱中表达最高（66.66％），其次是神经根囊肿（41.66％）和牙源性角化囊肿（16.6％）。关于染色和表达模式的评估，在牙质囊肿中显示出最高的阳性，在浅层（60％）和浅层（40％）中可见阳性，而在浅层和棘层中显示出阳性。
■细胞角蛋白-7的表达与上皮的分化程度相关。因此,具有高分化上皮(RC和DC)的囊肿表达CK-7,而具有低分化上皮(OKC)的囊肿显示轻微阳性。因此,将OKC与DC和RC区分开可能是有用的。
