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Abstract：
Background: Epithelial cells typically express E-cadherin where as N-cadherin expressed by mesenchymal cells.
The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell
adhesion, and gain migratory and invasive properties to become mesenchymal cells. EMT is typical for carcinoma cells
during tumor progression and correlate with the local invasiveness and metastatic potential of the tumor. Oral squamous
cell carcinoma is a malignant neoplasm arising from the mucosal epithelium of the oral cavity. It can be classified
as well; moderate and poor depends on a tumor cells resemblance to its tissue of origin. Materials and Methods: A
total of 130 cases of histopathologically diagnosed as OSCC were selected for the study, out of which 66,38 and 26
were well, moderate and poorly differentiated respectively. One section was stained with Haematoxylin and Eosin
and the other section for N-cadherin immunohistochemical study. Then the N-cadherin expression was correlated
histopathologically with different grades of OSCC. Statistical analysis was carried out mainly by Chi-Square analysis.
Results: Among the 66 cases of WDSCC mean value of N-cadherin expression was 1.79, 38 cases of MDSCC mean
value of N-cadherin expression was 4.16 and among the 26 cases of PDSCC the mean value was 6.38.That means the
value of N- cadherin expression was progressively increasing with decreased differentiation of the tumor cells. The
statistical analysis also shown it was highly significant (P<0.001). Conclusion: A correlative study of N-cadherin
expression with different grades of OSCC will be useful to predict the state of tumor progression and also it may give
accuracy for histopathogical grading of the tumor.
摘要：
背景：上皮细胞通常表达E-cadherin，而N-cadherin由间充质细胞表达。上皮向间充质转化（EMT）是上皮细胞失去其细胞极性和细胞间粘附的过程，并获得迁移和侵入特性，成为间充质细胞。EMT在肿瘤进展期间对于癌细胞是典型的,并且与肿瘤的局部侵袭性和转移潜力相关。口腔鳞状细胞癌是由口腔粘膜上皮引起的恶性肿瘤。它也可以分类;中度和差取决于肿瘤细胞与其起源组织的相似性。材料与方法:选择130例经组织病理学诊断为OSCC的患者作为研究对象,其中66,38和26很好，分别为中度和低分化。一个切片用苏木精和伊红染色,另一个切片用于N-钙黏着蛋白免疫组织化学研究。N-cadherin的表达在组织病理学上与不同级别的OSCC相关。统计分析主要采用卡方分析。结果：66例WDSCC中N-cadherin表达的平均值为1.79，38例MDSCC中N-cadherin表达的平均值为4.16，26例PDSCC中N-cadherin表达的平均值为6.38。这意味着N-钙粘蛋白表达的值随着肿瘤细胞分化的降低而逐渐增加。统计分析还显示其高度显著(P<0.001)。结论：N-cadherin表达与不同程度OSCC的相关性研究将有助于预测肿瘤的进展状态，并可能为肿瘤的组织病理学分级提供准确性。
