Abstract：
In recent years, large amounts of peptides have been purified and characterized from food protein hydrolysates. Many of these peptides have been demonstrated to be of potential application as health-improving ingredients against plenty of disease conditions, such as cancer, inflammation, and cardiovascular disease. The real efficacy of functional application of these peptides depends on their stability, transport, and bioavailability in target tissues, which in turn depends on the peptides characteristics. Therefore, the characteristic-function parameters are crucial for peptides using as functional agents. This review article intends to summarize the effects of peptide characteristics, including molecular weight, charge and hydrophobicity, on their stability, intestinal transport, and in vitro bioavailability. PRACTICAL APPLICATIONS: In the near future, bioactive peptides will play important roles in the area of functional foods and pharmacy. However, the gastrointestinal digestion and transport usually restrict their bioavailability in vivo. Understanding the relationships between peptide characteristics and their digestion stability, bioavailability may provide guidance and theoretical basis for the further application of bioactive peptides.
摘要：
近年来,大量的肽已经从食品蛋白水解产物中纯化和表征。这些肽中的许多已被证明具有潜在的应用作为改善健康的成分来对抗多种疾病，比如癌症，炎症,和心血管疾病。这些肽的功能应用的真正功效取决于它们的稳定性，运输,和目标组织的生物利用度，这又取决于肽的特性。因此,特征功能参数对于用作功能剂的肽至关重要。本文拟对影响肽的特性进行综述,包括分子量，电荷和疏水性，关于他们的稳定性，肠道运输，和体外生物利用度。实际应用：在不久的将来，生物活性肽将在功能性食品和药学领域发挥重要作用。然而,胃肠道的消化和运输通常限制了它们在体内的生物利用度。了解肽特性与其消化稳定性之间的关系，生物利用度可为生物活性肽的进一步应用提供指导和理论依据。
