关键词: Anti-G Antibody identification Hemolytic disease of the fetus and newborn (HDFN) Micro-column gel test Pregnancy

Mesh : Adult Erythroblastosis, Fetal / diagnosis pathology therapy Female Humans Infant, Newborn Isoantibodies / immunology Rh-Hr Blood-Group System / immunology

来  源:   DOI:10.1016/j.transci.2019.06.027   PDF(Sci-hub)

Abstract:
Anti-G is commonly present with anti-D and anti-C and can confuse serological investigations. The differentiation of anti-G from anti-D and anti-C is particularly essential for the accurate diagnosis of hemolytic disease of the fetus and newborn (HDFN) and appropriate administration of anti-D immunoglobulin prophylaxis in Rhesus (Rh) negative women. We reported a rare case of anti-G together with anti-D and anti-C in a pregnant woman and her female neonate. The titers of IgG anti-D, anti-C, and anti-G in the woman were 256, 128, and 32, respectively. While the titers of IgG anti-D, anti-C, and anti-G in the neonate were 16, 8, and 4, respectively. The neonate experienced mild HDFN and only received phototherapy during hospitalization. This report discusses the diagnostic strategy and clinical significance of differentiating anti-G from anti-D and anti-C.
摘要:
抗G通常与抗D和抗C-起存在,并且可混淆血清学研究。抗G与抗D和抗C的区别对于准确诊断胎儿和新生儿的溶血性疾病(HDFN)以及在恒河猴(Rh)阴性妇女中适当施用抗D免疫球蛋白预防特别重要。我们报道了一名孕妇及其女性新生儿中罕见的抗G和抗D和抗C病例。IgG抗-D的滴度,反C,女性的抗G分别为256、128和32。而IgG抗-D的滴度,反C,新生儿的抗G分别为16、8和4。新生儿经历轻度HDFN,仅在住院期间接受光疗。本报告讨论了区分抗G与抗D和抗C的诊断策略和临床意义。
公众号