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Abstract：
The superfamily of Transient Receptor Potential (TRP) channels is composed by a group of calcium-permeable ionic channels with a generally shared topology. The thermoTRP channels are a subgroup of 11 members, found in the TRPA, TRPV, TRPC, and TRPM subfamilies. Historically, members of this subgroup have been classified as cold, warm or hot-specific temperature sensors. Recently, new experimental results have shown that the role that has been given to the thermoTRPs in thermosensation is not necessarily strict. In addition, it has been shown that these channels activate over temperature ranges, which can have variations depending on the species and the interaction with a specific biological context. Investigation of these interactions could help to elucidate the mechanisms of activation by temperature, which remains uncertain. Abbreviations: Cryo-EM: Cryogenic electron microscopy; DRG: Dorsal root ganglia; H: Human; ROS: Reactive Oxygen Species; TG: Trigeminal ganglia; TRP: Transient Receptor Potential; TRPA: TRP ankyrin; TRPV: TRP vanilloid; TRPC: TRP canonical; TRPM: TRP melastatin.
摘要：
瞬时受体电位(TRP)通道的超家族由具有通常共享的拓扑结构的一组钙可渗透的离子通道组成。热TRP通道是一个由11个成员组成的亚组，在TRPA中发现,TRPV,TRPC,和TRPM亚家族。历史上,这个小组的成员被归类为感冒，温暖或热特定的温度传感器。最近,新的实验结果表明，热TRP在热感觉中的作用不一定严格。此外,已经表明，这些通道在温度范围内激活，取决于物种和与特定生物学环境的相互作用。研究这些相互作用有助于阐明温度激活的机制，这仍然不确定。缩写：Cryo-EM：低温电子显微镜；DRG：背根神经节；H：人；ROS：活性氧；TG：三叉神经节；TRP：瞬时受体电位；TRPA：TRP锚蛋白；TRPV：TRP香草素；TRPC：TRP规范；TRPM：TRPmelastatin。
