PDF(Pubmed)
Abstract：
Solitary fibrous tumor (SFT) is a rare, soft tissue neoplasm that rarely presents in breast tissue, with only 27 previously reported cases. To our knowledge, only one case of malignant SFT has been reported in the English literature. A 75-year-old Caucasian woman presented to our institution with a 3-month history of a palpable left breast mass. No other symptoms, including nipple discharge or skin changes, were noted. She underwent 3 previous biopsies for right breast masses, all of which were benign, with no evidence of spindle cell neoplasm, atypical hyperplasia, or malignancy. Microscopic examination of the mass demonstrated a classic area of SFT with areas of high-grade anaplastic component. In these areas, the tumor showed atypical epithelioid cells arranged in hypercellular sheets with diminished branching vasculature, nuclear pleomorphism, and increased mitotic count (up to 9/10 high-power fields). This case represents the second case of malignant SFT in the breast.
摘要：
孤立性纤维瘤（SFT）是一种罕见的，乳腺组织中很少出现的软组织肿瘤，以前报告的病例只有27例。据我们所知,英文文献中只有一例恶性SFT。一位75岁的白人妇女来到我们的机构，有3个月的可触及的左乳房肿块病史。没有其他症状,包括乳头溢液或皮肤变化，被注意到。她之前接受了3次右乳房肿块活检，所有这些都是良性的，没有梭形细胞肿瘤的证据,不典型增生,或者恶性肿瘤。肿块的显微镜检查表明，SFT的经典区域具有高级间变性组件的区域。在这些地区,肿瘤显示非典型上皮样细胞排列在高细胞片中，分支脉管系统减少，核多态性，和增加的有丝分裂计数（高达9/10的高功率场）。该病例代表第二例乳腺恶性SFT。
