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Abstract：
Biofilm infections are responsible for at least 65% of human bacterial infections. These biofilms are refractory to conventional antibiotics, leading to chronic infections and nonhealing wounds. Plant-derived antibiotics (phytochemicals) are promising alternative antimicrobial treatments featuring antimicrobial properties. However, their poor solubility in aqueous media limits their application in treating biofilm infections. Phytochemicals were incorporated into cross-linked polymer nanocomposite \"sponges\" for the treatment of bacterial biofilms. The results indicated encapsulating low log P phytochemicals effectively eliminated biofilms while demonstrating low cytotoxicity against mammalian fibroblast cells.
摘要：
生物膜感染负责至少65%的人类细菌感染。这些生物膜对常规抗生素是难处理的，导致慢性感染和伤口不愈合。植物衍生的抗生素（植物化学物质）是具有抗微生物特性的有前途的替代抗微生物治疗。然而,它们在水性介质中的溶解性差限制了它们在治疗生物膜感染中的应用。将植物化学物质掺入交联聚合物纳米复合材料“海绵”中，用于处理细菌生物膜。结果表明,包封低logP植物化学物质有效地消除了生物膜,同时表现出对哺乳动物成纤维细胞的低细胞毒性。
