PAR - 2 促进细胞增殖 ,迁移,并通过激活 PI3K / AKT 信号通路在口腔鳞状细胞癌中的侵袭。
关键词: Cell proliferation Invasion Migration Oral squamous cell carcinoma PAR-2 PI3K/AKT pathway
Mesh : Aged Carcinoma, Squamous Cell / genetics pathology Cell Line, Tumor Cell Movement / genetics Cell Proliferation / genetics Female Humans Keratinocytes / metabolism pathology Male Middle Aged Mouth Neoplasms / genetics pathology Neoplasm Invasiveness / genetics pathology Phosphatidylinositol 3-Kinases / genetics Phosphorylation / genetics Proto-Oncogene Proteins c-akt / genetics Receptor, PAR-2 / agonists genetics Signal Transduction
来 源:
DOI:10.1042/BSR20182476
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