关键词： Extended-spectrum beta-lactamases antibiotic carbapenem infections intravenous prosthetic joint infections

Mesh ： Administration, Intravenous Aged Anti-Bacterial Agents / administration & dosage therapeutic use Carbapenems / administration & dosage therapeutic use Combined Modality Therapy Drug Resistance, Multiple, Bacterial Enterobacteriaceae Infections / therapy Female Humans Infusions, Intralesional Joint Prosthesis / microbiology Male Practice Guidelines as Topic Prosthesis-Related Infections / therapy Reoperation / instrumentation Retrospective Studies

来  源：   DOI：10.2174/1871526519666190613121936

Abstract：
The aim of this paper is to establish guidelines for the management of extendedspectrum beta-lactamases (ESBL) associated prosthetic joint infections (PJI). This study reviewed 21 patients in the literature documented with ESBL associated PJI. Literature suggests that patients with ESBL PJI are stratified into either early infections (<3 weeks) or late infections (>3 weeks), for which, appropriate laboratory and imaging studies need to be completed. Favorable outcomes require a two-stage revision with an antibiotic-impregnated spacer and a prolonged course of intravenous carbapenem antibiotic.
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