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Abstract：
BACKGROUND: Migraine is a condition frequently associated with gastrointestinal disorders. Previous reports have shown the relationship between irritable bowel syndrome and migraine, but no data are yet available in patients with functional dyspepsia. We therefore evaluated whether alteration of gastric sensorimotor activity may be related to migraine.
METHODS: Sixty patients affected by functional dyspepsia, 38 with postprandial distress syndrome and 22 with epigastric pain syndrome were enrolled in a cohort study. Presence and severity of dyspeptic symptoms, migraine presence and severity, gastric sensitivity thresholds during fasting and postprandial period, gastric accommodation and gastric emptying time were evaluated.
RESULTS: In epigastric pain syndrome, 12/22 (54%) patients suffered from migraine and this condition was never correlated with meal ingestion. In postprandial distress syndrome patients, 29/38 (76%) suffered from migraine, in 26/29 (89%) its onset was considered as meal-related, and migraine severity was significantly correlated with postprandial modification of the gastric discomfort threshold (r = -0.73; p < 0.001). In patients with postprandial distress syndrome, in the subgroup with moderate to severe migraine, the severity of fullness and early satiation was significantly higher than in patients with mild or absent migraine. In patients with moderate to severe migraine, gastric accommodation, sensitivity thresholds and gastric emptying time were similar to patients with mild or no migraine.
CONCLUSIONS: In patients with functional dyspepsia and postprandial symptoms, migraine is a very frequent comorbidity. On clinical grounds, it is associated with an increased severity of fullness and early satiation and, on pathophysiological grounds, it seems correlated with postprandial hypersensitivity.
METHODS: Sixty patients affected by functional dyspepsia, 38 with postprandial distress syndrome and 22 with epigastric pain syndrome were enrolled in a cohort study. Presence and severity of dyspeptic symptoms, migraine presence and severity, gastric sensitivity thresholds during fasting and postprandial period, gastric accommodation and gastric emptying time were evaluated.
RESULTS: In epigastric pain syndrome, 12/22 (54%) patients suffered from migraine and this condition was never correlated with meal ingestion. In postprandial distress syndrome patients, 29/38 (76%) suffered from migraine, in 26/29 (89%) its onset was considered as meal-related, and migraine severity was significantly correlated with postprandial modification of the gastric discomfort threshold (r = -0.73; p < 0.001). In patients with postprandial distress syndrome, in the subgroup with moderate to severe migraine, the severity of fullness and early satiation was significantly higher than in patients with mild or absent migraine. In patients with moderate to severe migraine, gastric accommodation, sensitivity thresholds and gastric emptying time were similar to patients with mild or no migraine.
CONCLUSIONS: In patients with functional dyspepsia and postprandial symptoms, migraine is a very frequent comorbidity. On clinical grounds, it is associated with an increased severity of fullness and early satiation and, on pathophysiological grounds, it seems correlated with postprandial hypersensitivity.
摘要：
背景：偏头痛是一种经常与胃肠道疾病相关的疾病。以前的报道表明肠易激综合征和偏头痛之间的关系，但目前尚无功能性消化不良患者的数据.因此，我们评估了胃感觉运动活动的改变是否与偏头痛有关。
方法：60例功能性消化不良患者，一项队列研究纳入了38例餐后窘迫综合征和22例上腹痛综合征。消化不良症状的存在和严重程度，偏头痛的存在和严重程度，空腹和餐后期间的胃敏感性阈值，评估胃调节和胃排空时间。
结果：在上腹痛综合征中，12/22（54％）患者患有偏头痛，这种情况与进餐无关。在餐后窘迫综合征患者中，29/38（76％）患有偏头痛，在26/29(89%)，它的发作被认为与膳食有关，偏头痛严重程度与餐后胃部不适阈值的改变显着相关（r=-0.73；p<0.001）。在餐后窘迫综合征患者中，在中度至重度偏头痛的亚组中，饱腹感和早期饱足感的严重程度明显高于轻度或无偏头痛患者。在中度至重度偏头痛患者中，胃调节，敏感阈值和胃排空时间与轻度或无偏头痛患者相似.
结论：在功能性消化不良和餐后症状的患者中，偏头痛是一种常见的合并症。在临床上，它与饱腹感和早期饱腹感的严重程度增加有关，基于病理生理学的理由，它似乎与餐后过敏有关。
方法：60例功能性消化不良患者，一项队列研究纳入了38例餐后窘迫综合征和22例上腹痛综合征。消化不良症状的存在和严重程度，偏头痛的存在和严重程度，空腹和餐后期间的胃敏感性阈值，评估胃调节和胃排空时间。
结果：在上腹痛综合征中，12/22（54％）患者患有偏头痛，这种情况与进餐无关。在餐后窘迫综合征患者中，29/38（76％）患有偏头痛，在26/29(89%)，它的发作被认为与膳食有关，偏头痛严重程度与餐后胃部不适阈值的改变显着相关（r=-0.73；p<0.001）。在餐后窘迫综合征患者中，在中度至重度偏头痛的亚组中，饱腹感和早期饱足感的严重程度明显高于轻度或无偏头痛患者。在中度至重度偏头痛患者中，胃调节，敏感阈值和胃排空时间与轻度或无偏头痛患者相似.
结论：在功能性消化不良和餐后症状的患者中，偏头痛是一种常见的合并症。在临床上，它与饱腹感和早期饱腹感的严重程度增加有关，基于病理生理学的理由，它似乎与餐后过敏有关。
