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Abstract：
UNASSIGNED: Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers are difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remains an area of interest.This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.
RESULTS: Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.
CONCLUSIONS: Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.
RESULTS: Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.
CONCLUSIONS: Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.
摘要：
■动员外周血是血液移植干细胞和祖细胞的主要来源。成功的移植需要足够高质量的干细胞来概括终身造血，但是在一些病人和正常捐赠者中，达到临界阈值的干细胞数量是很难实现的。新颖的策略，特别是那些提供快速动员和降低成本的人，仍然是一个感兴趣的领域。这篇综述总结了理解干细胞动员过程的关键科学基础，专注于新的或改进的策略，以有效地收集和雕刻。
结果：所描述的研究为干细胞动员的复杂性提供了新的见解。针对HSC出口等新途径的代理商，确定收集更有效的竞争性HSC的策略，并正在评估优化干细胞收集和移植的新方法。
结论：已经确定了直接解决造血干细胞动员和移植的当前缺点的药物和更有效的策略，并提供了促进动员的干细胞的收集和扩大使用的潜力。
结果：所描述的研究为干细胞动员的复杂性提供了新的见解。针对HSC出口等新途径的代理商，确定收集更有效的竞争性HSC的策略，并正在评估优化干细胞收集和移植的新方法。
结论：已经确定了直接解决造血干细胞动员和移植的当前缺点的药物和更有效的策略，并提供了促进动员的干细胞的收集和扩大使用的潜力。
