PDF(Pubmed)
Abstract：
Therapeutic hypothermia has consistently been shown to be a robust neuroprotectant in many labs studying different models of neurological disease. Although this therapy has shown great promise, there are still challenges at the clinical level that limit the ability to apply this routinely to each pathological condition. In order to overcome issues involved in hypothermia therapy, understanding of this attractive therapy is needed. We review methodological concerns surrounding therapeutic hypothermia, introduce the current status of therapeutic cooling in various acute brain insults, and review the literature surrounding the many underlying molecular mechanisms of hypothermic neuroprotection. Because recent work has shown that body temperature can be safely lowered using pharmacological approaches, this method may be an especially attractive option for many clinical applications. Since hypothermia can affect multiple aspects of brain pathophysiology, therapeutic hypothermia could also be considered a neuroprotection model in basic research, which would be used to identify potential therapeutic targets. We discuss how research in this area carries the potential to improve outcome from various acute neurological disorders.
摘要：
在许多研究神经系统疾病不同模型的实验室中，治疗性低温一直被证明是一种强大的神经保护剂。尽管这种疗法显示出巨大的希望，在临床层面仍然存在挑战,这限制了将其常规应用于每种病理状况的能力.为了克服低温治疗中涉及的问题，需要了解这种有吸引力的疗法。我们回顾了围绕治疗性低温的方法学问题，介绍各种急性脑损伤治疗降温的现状，并回顾了有关低温神经保护的许多潜在分子机制的文献。因为最近的工作表明，使用药理学方法可以安全地降低体温，这种方法对于许多临床应用来说可能是一个特别有吸引力的选择.由于体温过低可以影响脑部病理生理学的多个方面，治疗性低温也可以被认为是基础研究中的神经保护模型，这将用于确定潜在的治疗靶点。我们讨论了该领域的研究如何具有改善各种急性神经系统疾病预后的潜力。
