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Abstract：
Tendon injury is a very common type of sports trauma, and its incidence has increased over the past decades. Surgical reconstruction with tendon allograft has been increasingly used to restore the motor function and stability of the injured site. However, the risk of disease transmission caused by allogeneic tendon transplantation has been a major problem for tissue bank researchers and clinicians. In order to eliminate the risk of disease transmission, a process of terminal sterilization is necessary. Ionizing irradiation, including gamma irradiation and electron beam irradiation is the most commonly used method for the terminal sterilization, which has been widely proved to be able to effectively inactivate the contained pathogens. Nevertheless, some accompanying damage to the mechanical and histological properties of collagen fibers in tendons will be caused. Therefore, more and more studies have begun to pay attention to the protective effect of radiation protection agents, including the radical scavengers and cross-linking agents, in the irradiation sterilization of allogeneic tendons.
摘要：
肌腱损伤是一种非常常见的运动创伤，在过去的几十年里，它的发病率有所增加。同种异体肌腱的外科重建已越来越多地用于恢复受伤部位的运动功能和稳定性。然而,同种异体肌腱移植引起的疾病传播风险一直是组织库研究人员和临床医生面临的主要问题。为了消除疾病传播的风险，一个终端灭菌的过程是必要的。电离辐射，其中γ辐照和电子束辐照是最常用的终端灭菌方法,已被广泛证明能够有效灭活所含病原体。然而，会对肌腱中胶原纤维的机械和组织学特性造成一些伴随的损害。因此,越来越多的研究开始重视辐射防护剂的防护作用,包括自由基清除剂和交联剂，在同种异体肌腱的辐照灭菌中。
