关键词： Colon cancer stem cells Colorectal cancer Hedgehog pathway Notch pathway Wnt/beta-catenin pathway

Mesh ： Animals Antineoplastic Agents / pharmacology therapeutic use Biomarkers, Tumor Cell Transformation, Neoplastic / genetics immunology Clinical Studies as Topic Colonic Neoplasms / etiology metabolism pathology therapy Disease Susceptibility Drug Evaluation, Preclinical Gene Expression Regulation, Neoplastic Humans Molecular Targeted Therapy Neoplastic Stem Cells / metabolism pathology Signal Transduction Treatment Outcome Tumor Microenvironment / drug effects genetics

来  源：   DOI：10.1080/15384047.2019.1599660   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Despite incessant research, colon cancer still is one of the most common causes of fatalities in both men and women worldwide. Also, nearly 50% of patients with colorectal cancer show tumor recurrence. Recent investigations have highlighted the involvement of colon cancer stem cells (CCSCs) in cancer relapse and chemoresistance. CCSCs deliver a significant protumorigenic niche through persistent overexpression of self-renewal capabilities. Moreover, CSCs cross network with stromal cells, immune infiltrates, and cyotokine-chemokine, which potentiate their aggressive proliferative potential. Targeting CCSCs through small molecule inhibitors, miRNAs, and monoclonal antibodies (mAbs) in in vivo studies has generated compelling evidence for the effectiveness of these various treatments. This review effectively compiles the role of CCSC surface markers and dysregulated and/or upregulated pathways in the pathogenesis of colorectal cancer that can be used to target CCSCs for effective colorectal cancer treatment.
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