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Abstract：
UNASSIGNED: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response.
UNASSIGNED: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters.
UNASSIGNED: Serum IL-18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL-1α and IL-1β were observed between SSc and HC. In both SSc and HC serum, IL-1α and IL-1β were positively correlated, while in SSc, both cytokines negatively correlated with IL-18. Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL-1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL-1β. Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL-1α concentrations were more likely to have digital ulcers.
UNASSIGNED: Our data suggest that these IL-1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.
UNASSIGNED: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters.
UNASSIGNED: Serum IL-18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL-1α and IL-1β were observed between SSc and HC. In both SSc and HC serum, IL-1α and IL-1β were positively correlated, while in SSc, both cytokines negatively correlated with IL-18. Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL-1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL-1β. Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL-1α concentrations were more likely to have digital ulcers.
UNASSIGNED: Our data suggest that these IL-1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.
摘要：
■系统性硬化症（SSc）是一种以纤维化为特征的自身免疫性疾病，血管功能障碍和免疫失调。SSc的发病机制仍然知之甚少，尽管研究表明了先天免疫反应的作用。
■这里，我们测量了血清白细胞介素（IL）-1α，105例SSc患者和47例健康对照（HC）中的IL-1β和IL-18水平，并就多个临床参数进行了分析。
■SSc患者的血清IL-18浓度明显高于HC，而SSc和HC之间的IL-1α和IL-1β浓度没有显着差异。在SSc和HC血清中，IL-1α与IL-1β呈正相关,而在SSc,两种细胞因子均与IL-18呈负相关。血清IL-18与一氧化碳转移系数（KCO）和肺对一氧化碳的弥散能力（DLCO）均呈显着负相关。血清IL-1β与改良Rodnan皮肤评分(mRSS)呈正相关,特别是在亚型有限的患者中。DLCO,高血清IL-1β患者的KCO和三尖瓣反流（TR）速度显着升高。SSc低KCO患者血清IL-1α水平明显降低,且与KCO呈正相关。血清IL-1α浓度高的SSc患者更容易出现数字溃疡。
■我们的数据表明，这些IL-1家族细胞因子在SSc纤维化并发症的发病机制中可能具有不同的作用。
■这里，我们测量了血清白细胞介素（IL）-1α，105例SSc患者和47例健康对照（HC）中的IL-1β和IL-18水平，并就多个临床参数进行了分析。
■SSc患者的血清IL-18浓度明显高于HC，而SSc和HC之间的IL-1α和IL-1β浓度没有显着差异。在SSc和HC血清中，IL-1α与IL-1β呈正相关,而在SSc,两种细胞因子均与IL-18呈负相关。血清IL-18与一氧化碳转移系数（KCO）和肺对一氧化碳的弥散能力（DLCO）均呈显着负相关。血清IL-1β与改良Rodnan皮肤评分(mRSS)呈正相关,特别是在亚型有限的患者中。DLCO,高血清IL-1β患者的KCO和三尖瓣反流（TR）速度显着升高。SSc低KCO患者血清IL-1α水平明显降低,且与KCO呈正相关。血清IL-1α浓度高的SSc患者更容易出现数字溃疡。
■我们的数据表明，这些IL-1家族细胞因子在SSc纤维化并发症的发病机制中可能具有不同的作用。
