PDF(Sci-hub)
Abstract：
BACKGROUND: The low fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP) diet causes significant clinical improvement in patients with irritable bowel syndrome (IBS). Joint hypermobility syndrome (JHS), defined as musculoskeletal symptoms in a hypermobile individual in the absence of systemic rheumatological disease, may be associated with functional gastrointestinal symptoms, including IBS. The aim of this study is to examine whether JHS can affect the response to the low FODMAP diet in patients with IBS.
METHODS: In this retrospective study, we included patients with IBS according to Rome III criteria who had followed a low FODMAP diet. Symptoms scores were measured before and after the low FODMAP diet.
RESULTS: A total of 165 patients (130 females, age 44 ± 14 years) were included. Diarrhea predominant IBS (IBS-D) was present in 40.6% of our patients while JHS was present in 21.2%. The score for abdominal pain was higher for JHS compared to non-JHS prior to intervention (P = 0.011). Symptoms improved in both groups of patients after a low FODMAP diet (P < 0.0001). The largest effects were shown with significant decreases of the average score and bloating. When broken down by JHS and IBS type, a low FODMAP diet significantly improved pain, bloating, diarrhea, constipation, and the average score with the largest effect in JHS/constipation predominant IBS (IBS-C), JHS/mixed IBS and unclassified IBS (IBS-M), JHS/IBS-D, non-JHS/IBS-C and JHS/IBS-M, respectively.
CONCLUSIONS: Our study suggests that a low FODMAP diet has a greater effect on IBS symptoms in JHS than non-JHS patients.
METHODS: In this retrospective study, we included patients with IBS according to Rome III criteria who had followed a low FODMAP diet. Symptoms scores were measured before and after the low FODMAP diet.
RESULTS: A total of 165 patients (130 females, age 44 ± 14 years) were included. Diarrhea predominant IBS (IBS-D) was present in 40.6% of our patients while JHS was present in 21.2%. The score for abdominal pain was higher for JHS compared to non-JHS prior to intervention (P = 0.011). Symptoms improved in both groups of patients after a low FODMAP diet (P < 0.0001). The largest effects were shown with significant decreases of the average score and bloating. When broken down by JHS and IBS type, a low FODMAP diet significantly improved pain, bloating, diarrhea, constipation, and the average score with the largest effect in JHS/constipation predominant IBS (IBS-C), JHS/mixed IBS and unclassified IBS (IBS-M), JHS/IBS-D, non-JHS/IBS-C and JHS/IBS-M, respectively.
CONCLUSIONS: Our study suggests that a low FODMAP diet has a greater effect on IBS symptoms in JHS than non-JHS patients.
摘要：
背景：可发酵性低的低聚糖，二糖，单糖和多元醇（FODMAP）饮食对肠易激综合征（IBS）患者的临床改善显着。关节过度活动综合征（JHS），定义为在没有全身性风湿病的情况下，过度活动的个体的肌肉骨骼症状，可能与功能性胃肠道症状有关，包括IBS。这项研究的目的是检查JHS是否会影响IBS患者对低FODMAP饮食的反应。
方法：在这项回顾性研究中，我们纳入了符合罗马III标准且遵循低FODMAP饮食的IBS患者.在低FODMAP饮食之前和之后测量症状评分。
结果：总共165名患者（130名女性，年龄44±14岁）。腹泻型IBS（IBS-D）在40.6％的患者中存在，而JHS在21.2％的患者中存在。干预前JHS的腹痛评分高于非JHS（P=0.011）。两组患者在低FODMAP饮食后症状均得到改善(P<0.0001)。最大的效果表现为平均得分和腹胀的显着降低。按JHS和IBS类型细分时，低FODMAP饮食显着改善疼痛，腹胀,腹泻,便秘,和JHS/便秘型IBS（IBS-C）中影响最大的平均得分，JHS/混合IBS和未分类IBS（IBS-M），JHS/IBS-D,非JHS/IBS-C和JHS/IBS-M，分别。
结论：我们的研究表明，与非JHS患者相比，低FODMAP饮食对JHS患者IBS症状的影响更大。
方法：在这项回顾性研究中，我们纳入了符合罗马III标准且遵循低FODMAP饮食的IBS患者.在低FODMAP饮食之前和之后测量症状评分。
结果：总共165名患者（130名女性，年龄44±14岁）。腹泻型IBS（IBS-D）在40.6％的患者中存在，而JHS在21.2％的患者中存在。干预前JHS的腹痛评分高于非JHS（P=0.011）。两组患者在低FODMAP饮食后症状均得到改善(P<0.0001)。最大的效果表现为平均得分和腹胀的显着降低。按JHS和IBS类型细分时，低FODMAP饮食显着改善疼痛，腹胀,腹泻,便秘,和JHS/便秘型IBS（IBS-C）中影响最大的平均得分，JHS/混合IBS和未分类IBS（IBS-M），JHS/IBS-D,非JHS/IBS-C和JHS/IBS-M，分别。
结论：我们的研究表明，与非JHS患者相比，低FODMAP饮食对JHS患者IBS症状的影响更大。
