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Abstract：
BACKGROUND: Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the function of the peripheral immune system is significantly altered during pregnancy in order to protect the developing fetus from being rejected by the maternal immune system (Fallon et al. 17(1):7-17, 2002), and we have recently found a dramatic change in the central immune system during and just after pregnancy in female rats (Sherer et al. 66:201-209, 2017). We observed anhedonia in Sprague-Dawley rat dams on the day of birth that is associated with an increase in interleukin (IL)-6 expression in the brain on the day of birth (Posillico and Schwarz 298(Pt B):218-28, 2016).
OBJECTIVE: The goal of the current experiments was to determine whether inhibiting the IL-6 receptor could prevent onset of this postpartum anhedonia, or anhedonia precipitated by subchronic stress in non-pregnant females.
RESULTS: Treatment with an IL-6 receptor antibody attenuated postpartum anhedonia as characterized by a decrease in sucrose preference. In contrast, this antibody had no effect on the decrease in sucrose preference induced following a week of forced swim stress in non-pregnant female rats.
CONCLUSIONS: The results of these studies suggest that the molecular mechanisms that underlie the onset of anhedonia following birth or mild stress in female rats may be distinct.
OBJECTIVE: The goal of the current experiments was to determine whether inhibiting the IL-6 receptor could prevent onset of this postpartum anhedonia, or anhedonia precipitated by subchronic stress in non-pregnant females.
RESULTS: Treatment with an IL-6 receptor antibody attenuated postpartum anhedonia as characterized by a decrease in sucrose preference. In contrast, this antibody had no effect on the decrease in sucrose preference induced following a week of forced swim stress in non-pregnant female rats.
CONCLUSIONS: The results of these studies suggest that the molecular mechanisms that underlie the onset of anhedonia following birth or mild stress in female rats may be distinct.
摘要：
背景：近60-80%的女性经历过某种形式的悲伤，焦虑,或在孩子出生后的几周内快感缺失(Patel等人。23（2）：534-42，2012；Degner10：359；j4692，2017）；然而，产后这些情绪变化的确切机制尚不清楚。众所周知，为了保护发育中的胎儿免受母体免疫系统的排斥，外周免疫系统的功能在怀孕期间会发生显着变化（Fallon等人。17(1):7-17,2002),我们最近发现雌性大鼠在怀孕期间和之后的中枢免疫系统发生了戏剧性的变化（Sherer等人。66:201-209,2017)。我们观察到出生当天Sprague-Dawley大鼠大坝的快感缺失与出生当天大脑中白细胞介素（IL）-6表达的增加有关（Posillico和Schwarz298（PtB）：218-28，2016）。
目的：当前实验的目的是确定抑制IL-6受体是否可以预防产后快感缺失的发生，或非怀孕女性的亚慢性压力导致的快感缺乏症。
结果：用IL-6受体抗体治疗减轻了产后快感缺失，其特征是蔗糖偏好降低。相比之下,在非妊娠雌性大鼠中,该抗体对强迫游泳应激一周后诱导的蔗糖偏好降低没有影响.
结论：这些研究的结果表明，雌性大鼠出生后快感缺乏或轻度应激的分子机制可能是不同的。
目的：当前实验的目的是确定抑制IL-6受体是否可以预防产后快感缺失的发生，或非怀孕女性的亚慢性压力导致的快感缺乏症。
结果：用IL-6受体抗体治疗减轻了产后快感缺失，其特征是蔗糖偏好降低。相比之下,在非妊娠雌性大鼠中,该抗体对强迫游泳应激一周后诱导的蔗糖偏好降低没有影响.
结论：这些研究的结果表明，雌性大鼠出生后快感缺乏或轻度应激的分子机制可能是不同的。
