METHODS: Plasma samples were obtained from patients at Royal Manchester Children\'s Hospital and analysed for AMH using the automated Beckman Coulter Access AMH Assay. Patients under investigation for paediatric reproductive or endocrine disorders were excluded from the study.
METHODS: Seven hundred and 2 patient plasma samples (465 male, 237 female) were subject to AMH measurement, and results were analysed in order to derive continuous and discrete reference intervals for the paediatric age range.
RESULTS: Clear discrimination between male and female AMH results was evident in the prepubertal age range, with some overlap between the genders following pubertal onset.
CONCLUSIONS: We have derived age-related reference intervals for plasma AMH in the paediatric age range (0-18 years) using the automated Beckman Coulter Access AMH assay which will aid in the investigation of paediatric endocrine disorders such as disorders of sexual development.
方法:血浆样本来自皇家曼彻斯特儿童医院的患者,并使用自动BeckmanCoulterAccessAMH分析进行AMH分析。接受儿科生殖或内分泌疾病调查的患者被排除在研究之外。
方法:700和2名患者血浆样本(465名男性,237名女性)接受AMH测量,并对结果进行了分析,以得出儿科年龄范围的连续和离散参考区间。
结果:在青春期前的年龄范围内,男性和女性AMH结果之间有明显的区别。青春期开始后,性别之间有一些重叠。
结论:我们使用自动BeckmanCoulterAccessAMH测定法得出了儿科年龄范围(0-18岁)的血浆AMH的年龄相关参考间隔,这将有助于研究儿科内分泌疾病,例如性发育障碍。