The study was conducted between January 2010 and March 2016. The colonized group consisted of patients who had a CRE strain in their rectal swab cultures, whereas patients with negative rectal surveillance cultures for CRE who were concurrently hospitalized in the same units with the colonized group patients were included in the control group.
The number of patients in the colonized and the control group was 71 and 120, respectively. Both groups were evaluated for demographic and healthcare-associated characteristics. Isolated microorganisms in rectal surveillance cultures for CRE were Klebsiella pneumoniae (75.5%), Escherichia coli (15.5%), Enterobacter cloacae (4.2%), Klebsiella oxytoca (1.4%), and Klebsiella terrigena (1.4%). The isolates were resistant to imipenem, meropenem, and ertapenem (52.1%, 73.2%, and 100%, respectively). In multivariate analysis, presence of decubitus, colistin usage, glycopeptide usage, and fluoroquinolone usage were found to be independent risk factors for CRE colonization. There was no significant difference between the two groups with regards to mortality (P = 0.070).
These results are in agreement with the current literature. The findings of this study could be useful for improvement of infection control strategies related to CRE
该研究于2010年1月至2016年3月进行。定殖组包括直肠拭子培养中有CRE菌株的患者,而与定植组患者同时在同一病房住院的CRE直肠监测培养阴性的患者被纳入对照组.
定植组和对照组的患者数分别为71和120。对两组进行人口统计学和医疗保健相关特征评估。在CRE的直肠监测培养物中分离的微生物是肺炎克雷伯菌(75.5%),大肠杆菌(15.5%),阴沟肠杆菌(4.2%),氧化克雷伯菌(1.4%),和克雷伯氏菌(1.4%)。分离株对亚胺培南有抗性,美罗培南,和厄他培南(52.1%,73.2%,100%,分别)。在多变量分析中,褥疮的存在,粘菌素用法,糖肽的使用,和氟喹诺酮的使用被发现是CRE定植的独立危险因素。两组在死亡率方面无显著差异(P=0.070)。
这些结果与当前文献一致。这项研究的结果可能有助于改善与CRE相关的感染控制策略