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Abstract：
TIM-family proteins are expressed on different immune cells such as dendritic cells, macrophages, type 1 and 2 T helper (Th) cells. Therefore, they have the ability to contribute to the various intracellular signals and immune responses, importantly the regulation of Th1 and Th17 cell differentiation, which plays a remarked role in fight against inflammatory and autoimmune diseases. Association of TIM family gene polymorphisms with rheumatoid arthritis (RA) has been frequently investigated. The findings however are not entirely consistent. Therefore, we carried out the present meta-analysis to examine the association between RA and the following TIM family gene polymorphisms: rs41297579, rs1036199, rs10515746, and rs7700944.
A systematic search of Scopus, PubMed, and Web of Science databases was conducted through December 2018. Combined odds ratios (OR) with their corresponding 95% confidence intervals (CI) were calculated under different possible genetic models.
A total of eight case-control studies were included in the present meta-analysis. The results demonstrated significant association of RA with TIM-3 rs1036199 polymorphism under dominant (OR, 1.93, 95% CI, 1.43-2.61) and allelic models (OR, 1.74, 95% CI, 1.31-2.30). None of the other examined polymorphisms indicated significant association with RA.
The present meta-analysis revealed that the TIM-3 rs1036199 polymorphism might confer susceptibility to RA. Further studies are required to reassert our findings.
A systematic search of Scopus, PubMed, and Web of Science databases was conducted through December 2018. Combined odds ratios (OR) with their corresponding 95% confidence intervals (CI) were calculated under different possible genetic models.
A total of eight case-control studies were included in the present meta-analysis. The results demonstrated significant association of RA with TIM-3 rs1036199 polymorphism under dominant (OR, 1.93, 95% CI, 1.43-2.61) and allelic models (OR, 1.74, 95% CI, 1.31-2.30). None of the other examined polymorphisms indicated significant association with RA.
The present meta-analysis revealed that the TIM-3 rs1036199 polymorphism might confer susceptibility to RA. Further studies are required to reassert our findings.
摘要：
TIM家族蛋白在不同的免疫细胞如树突状细胞上表达,巨噬细胞，1型和2型T辅助（Th）细胞。因此,它们有能力促进各种细胞内信号和免疫反应，重要的是调节Th1和Th17细胞的分化，在对抗炎症和自身免疫性疾病中起着重要作用。TIM家族基因多态性与类风湿关节炎（RA）的相关性已被频繁研究。然而，调查结果并不完全一致。因此,我们进行了本荟萃分析,以检查RA与以下TIM家族基因多态性之间的关联:rs41297579,rs1036199,rs10515746和rs7700944.
对Scopus的系统搜索，PubMed,和WebofScience数据库进行到2018年12月。在不同的可能遗传模型下计算了组合比值比（OR）及其相应的95％置信区间（CI）。
本荟萃分析共纳入8项病例对照研究。结果表明RA与显性TIM-3rs1036199多态性（OR，1.93，95%CI，1.43-2.61)和等位基因模型(OR，1.74，95%CI，1.31-2.30）。其他检查的多态性均未表明与RA存在显着关联。
目前的荟萃分析显示，TIM-3rs1036199多态性可能赋予RA易感性。需要进一步的研究来重申我们的发现。
对Scopus的系统搜索，PubMed,和WebofScience数据库进行到2018年12月。在不同的可能遗传模型下计算了组合比值比（OR）及其相应的95％置信区间（CI）。
本荟萃分析共纳入8项病例对照研究。结果表明RA与显性TIM-3rs1036199多态性（OR，1.93，95%CI，1.43-2.61)和等位基因模型(OR，1.74，95%CI，1.31-2.30）。其他检查的多态性均未表明与RA存在显着关联。
目前的荟萃分析显示，TIM-3rs1036199多态性可能赋予RA易感性。需要进一步的研究来重申我们的发现。
