A systematic search of Scopus, PubMed, and Web of Science databases was conducted through December 2018. Combined odds ratios (OR) with their corresponding 95% confidence intervals (CI) were calculated under different possible genetic models.
A total of eight case-control studies were included in the present meta-analysis. The results demonstrated significant association of RA with TIM-3 rs1036199 polymorphism under dominant (OR, 1.93, 95% CI, 1.43-2.61) and allelic models (OR, 1.74, 95% CI, 1.31-2.30). None of the other examined polymorphisms indicated significant association with RA.
The present meta-analysis revealed that the TIM-3 rs1036199 polymorphism might confer susceptibility to RA. Further studies are required to reassert our findings.
对Scopus的系统搜索,PubMed,和WebofScience数据库进行到2018年12月。在不同的可能遗传模型下计算了组合比值比(OR)及其相应的95%置信区间(CI)。
本荟萃分析共纳入8项病例对照研究。结果表明RA与显性TIM-3rs1036199多态性(OR,1.93,95%CI,1.43-2.61)和等位基因模型(OR,1.74,95%CI,1.31-2.30)。其他检查的多态性均未表明与RA存在显着关联。
目前的荟萃分析显示,TIM-3rs1036199多态性可能赋予RA易感性。需要进一步的研究来重申我们的发现。