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Abstract：
BACKGROUND: The authors aimed to conduct an extensive literature review and consensus meeting to identify unmet needs in ulcerative colitis (UC) and ways to overcome them. UC is a relapsing and remitting inflammatory bowel disease with varied, and changing, incidence rates worldwide. UC has an unpredictable disease course and is associated with a high health economic burden. During 2016 and 2017, a panel of experts was convened to identify, discuss and address areas of unmet need in UC.
METHODS: PubMed and Cochrane Library databases were searched for relevant articles describing studies performed in patients with UC. These findings were used to generate a set of statements relating to unmet needs in UC. Consensus on these statements was then sought from a panel of 9 expert gastroenterologists using a modified Delphi review process that consisted of anonymous surveys followed by live meetings.
RESULTS: In 2 literature reviews, over 5,000 unique records were identified and a total of 138 articles were fully reviewed. These were used to consider 26 areas of unmet need, which were explored in 2 face-to-face meetings, in which the statements were debated and amended, resulting in consensus on 30 final statements. The unmet needs identified were categorised into 7 areas: impact of UC on patients\' daily life; importance of early diagnosis and treatment; drawbacks of existing treatments; urgent need for new treatments; and disease-, practice- or patient-focused unmet needs.
CONCLUSIONS: These expert group meetings found a number of areas of unmet needs in UC, which is an important first step in tackling them in the future. Future research and development should be focused in these areas for the management of patients with UC.
METHODS: PubMed and Cochrane Library databases were searched for relevant articles describing studies performed in patients with UC. These findings were used to generate a set of statements relating to unmet needs in UC. Consensus on these statements was then sought from a panel of 9 expert gastroenterologists using a modified Delphi review process that consisted of anonymous surveys followed by live meetings.
RESULTS: In 2 literature reviews, over 5,000 unique records were identified and a total of 138 articles were fully reviewed. These were used to consider 26 areas of unmet need, which were explored in 2 face-to-face meetings, in which the statements were debated and amended, resulting in consensus on 30 final statements. The unmet needs identified were categorised into 7 areas: impact of UC on patients\' daily life; importance of early diagnosis and treatment; drawbacks of existing treatments; urgent need for new treatments; and disease-, practice- or patient-focused unmet needs.
CONCLUSIONS: These expert group meetings found a number of areas of unmet needs in UC, which is an important first step in tackling them in the future. Future research and development should be focused in these areas for the management of patients with UC.
摘要：
背景：作者旨在进行广泛的文献综述和共识会议，以确定溃疡性结肠炎（UC）中未满足的需求以及克服这些需求的方法。UC是一种复发和缓解的炎症性肠病，和改变，全球发病率。UC具有不可预测的病程并且与高健康经济负担相关。在2016年和2017年期间，召集了一个专家小组来确定，讨论和解决UC中未满足的需求领域。
方法：检索PubMed和CochraneLibrary数据库中描述UC患者研究的相关文章。这些发现用于生成与UC中未满足的需求有关的一组陈述。然后，由9名胃肠病专家组成的小组使用改良的Delphi审查程序，对这些陈述达成共识，该程序包括匿名调查，然后进行现场会议。
结果：在2篇文献综述中，超过5,000个独特的记录被确定和总共138篇文章被全面审查。这些被用来考虑26个未满足需求的领域，在两次面对面的会议中进行了探讨，在这些声明中进行了辩论和修改，就30项最后声明达成共识。确定的未满足的需求分为7个方面：UC对患者日常生活的影响；早期诊断和治疗的重要性；现有治疗方法的缺点；迫切需要新的治疗方法；和疾病-以实践或患者为中心的未满足需求。
结论：这些专家小组会议发现了UC的许多未满足的需求领域，这是未来解决这些问题的重要第一步。未来的研究和开发应集中在这些领域，以管理UC患者。
方法：检索PubMed和CochraneLibrary数据库中描述UC患者研究的相关文章。这些发现用于生成与UC中未满足的需求有关的一组陈述。然后，由9名胃肠病专家组成的小组使用改良的Delphi审查程序，对这些陈述达成共识，该程序包括匿名调查，然后进行现场会议。
结果：在2篇文献综述中，超过5,000个独特的记录被确定和总共138篇文章被全面审查。这些被用来考虑26个未满足需求的领域，在两次面对面的会议中进行了探讨，在这些声明中进行了辩论和修改，就30项最后声明达成共识。确定的未满足的需求分为7个方面：UC对患者日常生活的影响；早期诊断和治疗的重要性；现有治疗方法的缺点；迫切需要新的治疗方法；和疾病-以实践或患者为中心的未满足需求。
结论：这些专家小组会议发现了UC的许多未满足的需求领域，这是未来解决这些问题的重要第一步。未来的研究和开发应集中在这些领域，以管理UC患者。
