Remission of type 2 diabetes and pleiotropic effects of long-term testosterone treatment for "late-onset" hypogonadism: A case report.

2 型糖尿病的缓解和长期睾酮治疗 “迟发性 ” 性腺功能减退的多效性作用 ： 一例报告。

• 发表时间: 2019
• 来源期刊: SAGE Open Med Case Rep
• DOI: 10.1177/2050313X18823454
• PMID: 30719309
• 文章类型: Case Reports
• 作者列表: Haider A,Haider K,Saad F,Hanefeld M

关键词: Testosterone therapy; cardiometabolic risk factors; obesity; type 2 diabetes; “late-onset” hypogonadism

Abstract

For obese type 2 diabetes patients, weight reduction is one of the most important measures but fails in most cases. Testosterone deficiency can be the reason for such failure. This case presents a 57-year-old man who was referred to a urologist due to benign prostatic hyperplasia and erectile dysfunction. He had type 2 diabetes, was overweight, and had hypertension and dyslipidemia. The blood test revealed testosterone deficiency. Under testosterone therapy, the patient lost 10 kg; cardiometabolic parameters returned to normal and lower urinary tract symptoms disappeared; complete remission of diabetes was recorded. Overweight and obese patients with type 2 diabetes should be tested for hypogonadism and testosterone therapy, if indicated, be considered. These patients can considerably benefit from testosterone therapy in terms of sustainable weight loss and a clinically significant reduction of cardiometabolic risk factors including complete remission of diabetes.

摘要

对于肥胖的2型糖尿病患者，减轻体重是最重要的措施之一，但在大多数情况下失败。睾酮缺乏可能是这种失败的原因。该病例为一名57岁的男子，由于良性前列腺增生和勃起功能障碍而被转诊给泌尿科医生。他有2型糖尿病,超重，患有高血压和血脂异常。血液检查显示睾丸激素缺乏。在睾酮治疗下,患者减重10公斤;心脏代谢参数恢复正常,下尿路症状消失;记录糖尿病完全缓解.超重和肥胖的2型糖尿病患者应进行性腺功能减退和睾酮治疗测试，如果指示，被考虑。这些患者在可持续的体重减轻和临床上显着减少心脏代谢风险因素（包括糖尿病的完全缓解）方面可以从睾酮治疗中受益。