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Abstract：
OBJECTIVE: The systematic review of randomized clinical trials is crucial to assess the safety and effectiveness of intermediate procedures. The objective of this article is to present a tutorial for the planning and execution of systematic review and meta-analysis of randomized clinical trial studies.
BACKGROUND: The systematic literature review is the type of research that organizes, criticizes, and integrates available evidence published in the health field. Systematization leads to less bias, however, the quality of systematic reviews may not always be perceived due to the way it is described in the articles. The information disclosed in the articles is not always free of bias. The steps for carrying out a systematic review include design, protocol registration, implementation, mathematical analysis of results, and dissemination. PRISMA statement has improved the quality of systematic review reports by providing a list of items to be described, and this article emphasizes the key steps for performing a systematic review of interventions.
CONCLUSIONS: The evidence generated through a systematic review can provide the clinician with greater confidence in decision making at the moment of clinical practice and optimize the benefits to his patients, serving as a tool to assist managers in making decisions regarding the implementation of new strategies in favor of the public health.
BACKGROUND: The systematic literature review is the type of research that organizes, criticizes, and integrates available evidence published in the health field. Systematization leads to less bias, however, the quality of systematic reviews may not always be perceived due to the way it is described in the articles. The information disclosed in the articles is not always free of bias. The steps for carrying out a systematic review include design, protocol registration, implementation, mathematical analysis of results, and dissemination. PRISMA statement has improved the quality of systematic review reports by providing a list of items to be described, and this article emphasizes the key steps for performing a systematic review of interventions.
CONCLUSIONS: The evidence generated through a systematic review can provide the clinician with greater confidence in decision making at the moment of clinical practice and optimize the benefits to his patients, serving as a tool to assist managers in making decisions regarding the implementation of new strategies in favor of the public health.
摘要：
目的：随机临床试验的系统评价对于评估中间程序的安全性和有效性至关重要。本文的目的是为随机临床试验研究的系统评价和荟萃分析的计划和执行提供教程。
背景：系统文献综述是组织研究的类型，批评,并整合了卫生领域发表的现有证据。系统化导致更少的偏见，然而,由于文章中描述的方式，系统评价的质量可能并不总是被感知。文章中披露的信息并不总是没有偏见。进行系统审查的步骤包括设计，协议注册，实施，结果的数学分析，和传播。PRISMA声明通过提供要描述的项目清单，提高了系统审查报告的质量，本文强调了对干预措施进行系统审查的关键步骤。
结论：通过系统评价产生的证据可以为临床医生在临床实践时提供更大的决策信心，并优化患者的利益。作为一个工具，以协助管理人员作出决策有关实施有利于公共卫生的新战略。
背景：系统文献综述是组织研究的类型，批评,并整合了卫生领域发表的现有证据。系统化导致更少的偏见，然而,由于文章中描述的方式，系统评价的质量可能并不总是被感知。文章中披露的信息并不总是没有偏见。进行系统审查的步骤包括设计，协议注册，实施，结果的数学分析，和传播。PRISMA声明通过提供要描述的项目清单，提高了系统审查报告的质量，本文强调了对干预措施进行系统审查的关键步骤。
结论：通过系统评价产生的证据可以为临床医生在临床实践时提供更大的决策信心，并优化患者的利益。作为一个工具，以协助管理人员作出决策有关实施有利于公共卫生的新战略。
