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Abstract：
Autophagy is a well-conserved self-eating mechanism of cell survival during periods of nutrient deprivation, stress and injury. Autophagy is implicated in many pathophysiological conditions across all organ systems. The cornea is an avascular transparent tissue that is prone to damage by trauma, injury and infection. Following insult, the cornea undergoes a complex wound healing process, which is regulated by multiple factors including autophagy. The involvement of autophagy in keratoconus and HSV-1 infection has been demonstrated, underlining the importance of this mechanism in corneal disorders. However, the role of autophagy in corneal wound repair, fibrosis and angiogenesis is still unclear. Recently, we characterized the expression of autophagy-related genes in cornea and are studying their role in the modulation of corneal conditions including fibrosis and dystrophies. Preliminary results presented within this review article support further investigation of the dynamic modulation of autophagy-related genes in corneal health and disease. This article provides an overview of how autophagy modulates corneal function.
摘要：
自噬是营养剥夺期间细胞存活的一种保守的自食机制，压力和伤害。自噬涉及所有器官系统的许多病理生理条件。角膜是一种无血管的透明组织，容易受到创伤的损害，伤害和感染。侮辱之后，角膜经历了复杂的伤口愈合过程，受包括自噬在内的多种因素调节。已经证明自噬参与圆锥角膜和HSV-1感染，强调这种机制在角膜疾病中的重要性。然而,自噬在角膜创伤修复中的作用,纤维化和血管生成仍不清楚。最近,我们鉴定了自噬相关基因在角膜中的表达,并正在研究它们在调节角膜疾病(包括纤维化和营养不良)中的作用.本文的初步结果支持进一步研究自噬相关基因在角膜健康和疾病中的动态调节。本文概述了自噬如何调节角膜功能。
