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Abstract：
Autophagy, a highly conserved cellular mechanism, plays an essential role in the development and pathology of many central and peripheral nervous system diseases. The auditory system, especially hair cells (HCs) and spiral ganglion neurons (SGNs) in the inner ear, are postmitotic cells, which are extremely reliant on cellular homeostasis and energy supply. Therefore, autophagy may be involved in contributing to and facilitating the normal function of inner ear cells. Recently, studies on hearing loss induced by ototoxic drugs, noise exposure and other factors have revealed that autophagy could serve in an antioxidative capacity and could possess the potential to treat sensorineural hearing loss (SNHL). Therefore, here we review previous studies concerning autophagy and SNHL to gain insight into the role of autophagic mechanisms in inner ear disorders.
摘要：
自噬,一种高度保守的细胞机制，在许多中枢和外周神经系统疾病的发生发展和病理过程中起着至关重要的作用。听觉系统,特别是内耳的毛细胞（HC）和螺旋神经节神经元（SGNS），是有丝分裂后的细胞，非常依赖细胞稳态和能量供应。因此,自噬可能参与促进和促进内耳细胞的正常功能。最近,关于耳毒性药物引起的听力损失的研究，噪声暴露和其他因素表明,自噬可发挥抗氧化作用,并具有治疗感音神经性听力损失(SNHL)的潜力.因此,在这里，我们回顾了以前关于自噬和SNHL的研究，以深入了解自噬机制在内耳疾病中的作用。
