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Abstract：
Body mass and body fat composition are of clinical interest due to their links to cardiovascular- and metabolic diseases. Fat stored in the trunk has been suggested to be more pathogenic compared to fat stored in other compartments. In this study, we perform genome-wide association studies (GWAS) for the proportion of body fat distributed to the arms, legs and trunk estimated from segmental bio-electrical impedance analysis (sBIA) for 362,499 individuals from the UK Biobank. 98 independent associations with body fat distribution are identified, 29 that have not previously been associated with anthropometric traits. A high degree of sex-heterogeneity is observed and the effects of 37 associated variants are stronger in females compared to males. Our findings also implicate that body fat distribution in females involves mesenchyme derived tissues and cell types, female endocrine tissues as well as extracellular matrix maintenance and remodeling.
摘要：
身体质量和身体脂肪组成由于其与心血管和代谢疾病的联系而具有临床意义。与储存在其他隔室中的脂肪相比，储存在躯干中的脂肪被认为更具致病性。在这项研究中,我们对体脂肪分布到手臂的比例进行全基因组关联研究（GWAS），根据来自英国生物库的362,499人的分段生物电阻抗分析（sBIA）估计的腿和躯干。确定了98个与身体脂肪分布的独立关联，29，以前没有与人体测量学特征相关。观察到高度的性别异质性，与男性相比，女性中37种相关变异的影响更强。我们的发现还暗示，女性体内脂肪分布涉及间充质来源的组织和细胞类型，女性内分泌组织以及细胞外基质的维持和重塑。
