Abstract:
OBJECTIVE: The simple energy balance model of obesity is inconsistent with the available findings on obesity etiology, prevention, and treatment. Yet, the most commonly stated causes of pediatric obesity are predicated on this model. A more comprehensive biological model is needed upon which to base behavioral interventions aimed at obesity prevention. In this light, alternative etiologies are little investigated and thereby poorly understood.
RESULTS: Three candidate alternate etiologies are briefly presented: infectobesity, the gut microbiome, and circadian rhythms. Behavioral child obesity preventive investigators need to collaborate with biological colleagues to more intensively analyze the behavioral aspects of these etiologies and to generate innovative procedures for preventing a multi-etiological problem, e.g., group risk analysis, triaging for likely causes of obesity.
摘要:
目的:肥胖的简单能量平衡模型与现有的肥胖病因研究结果不一致,预防,和治疗。然而,儿童肥胖最常见的原因是基于该模型。需要一个更全面的生物学模型来建立旨在预防肥胖的行为干预措施。在这种情况下,替代病因研究甚少,因此了解甚少。
结果:简要介绍了三种候选的替代病因:感染性肥胖,肠道微生物组,和昼夜节律。行为儿童肥胖预防研究人员需要与生物学同事合作,更深入地分析这些病因的行为方面,并制定创新的程序来预防多病因问题。例如,群体风险分析,对肥胖的可能原因进行分类。