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Abstract：
Glioblastoma (GB) is the most aggressive primary brain tumor in adults. The aggressive nature of GB has been attributed to the presence of cancer stem cells (CSCs) which drive tumorigenesis and are thought to be the root cause of the disease. Circulating tumor stem cells (CTSCs), which can be derived from CSCs, have been identified in numerous types of cancer including GB, have been proposed to contribute to local and distant recurrence. There are many technical difficulties in studying CTSCs, therefore there is a significant gap in the literature pertaining to how they arise and function, and how the understanding of the biology of CTSCs could elucidate the underlying cause of local recurrence and metastasis. An initial epithelial-to-mesenchymal transition (EMT) followed by mesenchymal-to-epithelial transition involving these primitive cells appear to be the critical processes underpinning metastasis. This review focuses on the association between CSCs undergoing EMT to become CTSCs, and how this could arise from the CSC subpopulation in GB, and contribute to the understanding of the pathogenesis and treatment.
摘要：
胶质母细胞瘤（GB）是成年人中最具侵袭性的原发性脑肿瘤。GB的侵袭性归因于癌症干细胞(CSC)的存在,其驱动肿瘤发生并且被认为是疾病的根本原因。循环肿瘤干细胞（CTSC），可以来自CSC，已经在包括GB在内的许多类型的癌症中被发现，已被提议有助于局部和远处复发。研究CTSCs有许多技术困难,因此，关于它们是如何产生和起作用的文献中存在很大的差距，以及对CTSCs生物学的理解如何阐明局部复发和转移的根本原因。最初的上皮-间质转化（EMT），然后是涉及这些原始细胞的间质-上皮转化似乎是支撑转移的关键过程。本文综述了接受EMT的CSCs成为CTSCs之间的关系，以及这是如何从GB中的CSC亚群中产生的，并有助于了解其发病机制和治疗方法。
