PDF(Sci-hub)
Abstract：
OBJECTIVE: Despite extensive knowledge gained over the last 3 decades regarding limbal stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of agreement on the diagnostic criteria, staging, and classification system among treating physicians and research scientists working on this field. There is therefore an unmet need to obtain global consensus on the definition, classification, diagnosis, and staging of LSCD.
METHODS: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group.
RESULTS: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established.
CONCLUSIONS: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.
METHODS: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group.
RESULTS: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established.
CONCLUSIONS: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.
摘要：
目的：尽管在过去的30年中获得了关于角膜缘干细胞缺乏症（LSCD）的广泛知识，这种疾病没有明确定义，在诊断标准上缺乏共识，分期,以及在这一领域工作的治疗医生和研究科学家之间的分类系统。因此，就该定义达成全球共识的需要尚未满足，分类，诊断,和LSCD分期。
方法：角膜缘干细胞工作组于2012年由角膜学会首次成立。工作组分为小组委员会。四次面对面的会议,频繁的电子邮件讨论，此后进行了电话会议，以在进行全面的文献检索后，获得所有参与者对战略计划和方法的共识，并就定义达成了最终协议，分类，诊断,和LSCD分期。成立了一个写作小组来起草当前的手稿，经广泛修订，以反映工作组的共识。
结果：就定义达成共识，分类，诊断,和LSCD分期。明确了LSCD的临床表现和诊断标准。建立了基于临床表现的LSCD分期体系。
结论：这一全球共识为定义提供了一个全面的框架，分类，诊断,和LSCD分期。新建立的标准将有助于正确诊断和制定LSCD不同阶段的适当治疗方法，这将有助于更好地了解病情并有助于临床管理，研究,和这个领域的临床试验。
方法：角膜缘干细胞工作组于2012年由角膜学会首次成立。工作组分为小组委员会。四次面对面的会议,频繁的电子邮件讨论，此后进行了电话会议，以在进行全面的文献检索后，获得所有参与者对战略计划和方法的共识，并就定义达成了最终协议，分类，诊断,和LSCD分期。成立了一个写作小组来起草当前的手稿，经广泛修订，以反映工作组的共识。
结果：就定义达成共识，分类，诊断,和LSCD分期。明确了LSCD的临床表现和诊断标准。建立了基于临床表现的LSCD分期体系。
结论：这一全球共识为定义提供了一个全面的框架，分类，诊断,和LSCD分期。新建立的标准将有助于正确诊断和制定LSCD不同阶段的适当治疗方法，这将有助于更好地了解病情并有助于临床管理，研究,和这个领域的临床试验。
