PDF(Pubmed)
Abstract：
A titanium implant surface when coated with biodegradable, highly porous, osteogenic nanofibrous coating has shown enhanced intrinsic osteoinductive and osteoconductive properties. This coating mimics extracellular matrix resulting in differentiation of stem cells present in the peri-implant niche to osteoblast and hence results in enhanced osseointegration of the implant. The osteogenic nanofibrous coating (ONFC) consists of poly-caprolactone, gelatin, nano-sized hydroxyapatite, dexamethasone, ascorbic acid and beta-glycerophosphate. ONFC exhibits optimum mechanical properties to support mesenchymal stem cells and steer their osteogenic differentiation. ONFC was subjected to various characterization tests like scanning electron microscopy, Fourier-transform infrared spectroscopy, x-ray diffractometry, thermal degradation, biomineralization, mechanical properties, wettability and proliferation assay. In pre-clinical animal trials, the coated implant showed enhanced new bone formation when placed in the tibia of rabbit. This novel approach toward implant bone integration holds significant promise for its easy and economical coating thus marking the beginning of new era of electrospun osteogenic nanofibrous coated bone implants.
摘要：
钛植入物表面涂有可生物降解的，高度多孔,成骨纳米纤维涂层显示出增强的内在骨诱导性和骨传导性能。该涂层模拟细胞外基质,导致存在于植入物周围生态位中的干细胞分化为成骨细胞,并因此导致植入物的骨整合增强。成骨纳米纤维涂层（ONFC）由聚己内酯组成，明胶,纳米羟基磷灰石，地塞米松,抗坏血酸和β-甘油磷酸盐。ONFC表现出最佳的机械性能，以支持间充质干细胞并引导其成骨分化。ONFC接受了各种表征测试，如扫描电子显微镜，傅里叶变换红外光谱,x射线衍射法,热降解，生物矿化，机械性能，润湿性和增殖试验。在临床前动物试验中,当放置在兔胫骨中时，涂层植入物显示出增强的新骨形成。这种针对植入物骨整合的新颖方法因其容易且经济的涂层而具有重要的前景，因此标志着电纺成骨纳米纤维涂层骨植入物新时代的开始。
