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Abstract：
Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Certain abdominopelvic cancer surgeries are associated with a six to 14-fold increased risk of DVT versus surgeries for benign disease, and extended thromboprophylaxis using perioperative LMWHs may further reduce VTE rates over standard duration administration. This review assesses the value of extended low molecular weight heparin (LMWH) thromboprophylaxis as a recommended strategy after abdominopelvic cancer surgery.
Six eligible randomized controlled trials (RCTs), seven meta-analyses (MAs), and five non-randomized cohort studies were identified evaluating extended versus standard thromboprophylaxis following abdominopelvic cancer surgery.
Available evidence showed significantly reduced rates of VTE for extended versus standard LMWH thromboprophylaxis following abdominopelvic cancer surgery, with some studies showing trends toward reduced rates of symptomatic VTE events. Many of these studies showed significantly reduced rates of proximal DVT and some showed trends toward reduced PE, suggesting potentially important clinical benefits.
Six eligible randomized controlled trials (RCTs), seven meta-analyses (MAs), and five non-randomized cohort studies were identified evaluating extended versus standard thromboprophylaxis following abdominopelvic cancer surgery.
Available evidence showed significantly reduced rates of VTE for extended versus standard LMWH thromboprophylaxis following abdominopelvic cancer surgery, with some studies showing trends toward reduced rates of symptomatic VTE events. Many of these studies showed significantly reduced rates of proximal DVT and some showed trends toward reduced PE, suggesting potentially important clinical benefits.
摘要：
静脉血栓栓塞症(VTE)包括深静脉血栓形成(DVT)和肺栓塞(PE)。某些腹骨盆癌手术与良性疾病的手术相比，DVT的风险增加了6到14倍。和延长使用围手术期LMWH的血栓预防可能在标准持续时间给药期间进一步降低VTE发生率.这篇综述评估了延长低分子量肝素（LMWH）血栓预防作为腹盆腔癌手术后推荐策略的价值。
六项符合条件的随机对照试验（RCT），七项荟萃分析(MA)，并确定了5项非随机队列研究,评估了腹盆腔癌手术后延长与标准的血栓预防.
现有证据表明，与标准LMWH腹肾盂癌手术后的延长血栓预防相比，VTE的发生率显着降低，一些研究显示有症状的VTE事件发生率有降低的趋势。这些研究中的许多研究显示近端DVT的发生率显着降低，一些研究显示PE降低的趋势。提示潜在的重要临床益处。
六项符合条件的随机对照试验（RCT），七项荟萃分析(MA)，并确定了5项非随机队列研究,评估了腹盆腔癌手术后延长与标准的血栓预防.
现有证据表明，与标准LMWH腹肾盂癌手术后的延长血栓预防相比，VTE的发生率显着降低，一些研究显示有症状的VTE事件发生率有降低的趋势。这些研究中的许多研究显示近端DVT的发生率显着降低，一些研究显示PE降低的趋势。提示潜在的重要临床益处。
