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Abstract：
Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignancy typically occurring in young women. Occasionally, these neoplasms present with pleomorphic to atypical multinucleated giant tumor cells which may mimic high-grade malignancy. Our patient is a 25-year-old male who presented with one year of intermittent epigastric pain. Magnetic resonance imaging showed a 3.1 × 2.5 cm mass in the pancreas body. Endoscopic ultrasound-guided fine needle aspiration of the mass showed large pleomorphic cells and atypical multinucleated giant cells in a background of singly scattered polygonal cells. Focally, these cells surrounded delicate hyalinized to fibrovascular cores forming pseudopapillae. Immunohistochemical stains show tumor cells are positive for beta-catenin, CD10, vimentin, and CD56. Although rare surgical pathology publications have described the presence of pleomorphic to atypical multinucleated giant cells occurring in SPN, to our knowledge, this is the first case reported example focused on cytomorphologic illustration and description.
摘要：
胰腺实性假乳头状瘤（SPN）是一种罕见的低度恶性肿瘤，通常发生在年轻女性中。偶尔,这些肿瘤表现为多形性至非典型多核巨瘤细胞，可能模仿高级别恶性肿瘤。我们的患者是一名25岁的男性，患有间歇性上腹痛一年。磁共振成像显示胰腺体内有3.1×2.5cm的肿块。内窥镜超声引导的细针抽吸肿块显示，在单个分散的多边形细胞的背景下，大型多形性细胞和非典型多核巨细胞。集中,这些细胞包围着脆弱的玻璃化成纤维血管核，形成假乳头。免疫组织化学染色显示肿瘤细胞对β-连环蛋白呈阳性，CD10波形蛋白,CD56尽管罕见的外科病理学出版物描述了SPN中存在多形性到非典型多核巨细胞的存在，根据我们的知识，这是第一个病例报道的例子，集中于细胞形态学的说明和描述。
