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Abstract：
The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.
摘要：
胃炎的发展与胃癌的风险增加有关。今朝侵袭性胃炎的诊断办法不合适监测进步。这项工作基于78名胃炎患者和50名健康个体，我们观察到舌苔菌群的变化与胃炎的发生和发展有关。鉴定出21种微生物物种，用于区分胃炎和健康个体的舌衣微生物群。不同环境中的微生物代谢等途径，胃炎患者抗生素的生物合成和细菌趋化性上调。发现弯曲杆菌的丰度与胃癌前级联反应有关。此外，在包含38名胃炎患者的验证队列中，可以在舌衣和胃液中检测到弯曲菌。这些观察结果为中医舌诊提供了生物学证据,并表明舌苔微生物组可能是一种潜在的非侵入性生物标志物，这可能适用于胃炎的长期监测。
