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Abstract：
Objectives: The aims of the current study are to (1) report the frequency of specific sleep disturbance symptoms in Mild Cognitive Impairment (MCI) and cognitive healthy older persons; (2) examine whether overall poor sleep and specific sleep disturbance symptoms are more common in persons with MCI compared to cognitive healthy older controls and; (3) examine the association between sleep disturbances and performance in general and specific cognitive domains in persons with MCI and separately in cognitive healthy older persons. Methods: Data were collected at the Fondazione Ospedale San Camillo Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Venice, Italy as part of the European VPH-DARE@IT project. We included 69 persons with MCI (mean age 75.7; SD = 7.7) and 72 sex-matched cognitively healthy controls (mean age 71.8; SD = 7.0). Participants underwent extensive neuropsychological assessment and evaluation of subjective sleep performance with the Sleep Continuity in Alzheimer\'s Disease Scale(SCADS). Results: A fifth of MCI patients (21.7%, n = 15) had poor sleep compared to 15.3% (n = 11) of cognitively healthy controls. MCI patients had a 3.2 higher odds of having poor sleep compared to cognitively healthy controls after adjustment for age, education, sex, and general cognitive functioning (Odds Ratio (OR) = 3.2; 95% Confidence Interval (CI) = 1.1-9.2). Persons who reported waking up twice or more during the night had higher odds of being MCI compared to those who never wake or wake only once (OR = 2.6; 95% CI = 1.1-6.1). In MCI patients, poor sleep was associated with better general cognitive functioning and short-term working memory, whereas in cognitive healthy older persons poor sleep was associated with impairment in episodic memory performance and executive functioning. Discussion: Our results confirm previous studies showing that sleep disturbances are common in MCI, and this may be due to an ongoing neurodegenerative process rather than a symptom of cognitive impairment. Future research with objective sleep measurements are needed in MCI as well as interventions to improve sleep with the aim of preventing cognitive decline.
摘要：
目标：本研究的目的是（1）报告轻度认知障碍（MCI）和认知健康老年人中特定睡眠障碍症状的频率；（2）检查与认知健康老年人对照相比，MCI患者的总体睡眠不良和特定睡眠障碍症状是否更常见；（3）检查MCI患者和认知健康老年人的一般和特定认知领域的睡眠障碍与表现之间的关系。方法：数据是在圣卡米洛科学基金会（IRCCS）收集的，威尼斯,意大利是欧洲VPH-DARE@IT项目的一部分。我们纳入了69名MCI患者（平均年龄75.7；SD=7.7）和72名性别匹配的认知健康对照（平均年龄71.8；SD=7.0）。参与者接受了广泛的神经心理学评估，并使用阿尔茨海默病量表（SCADS）中的睡眠连续性评估了主观睡眠表现。结果：五分之一的MCI患者（21.7%，n=15）睡眠不足，而认知健康的对照组为15.3％（n=11）。调整年龄后，MCI患者睡眠不足的几率比认知健康的对照组高3.2。教育,性别,和一般认知功能（赔率比（OR）=3.2；95％置信区间（CI）=1.1-9.2）。与从未醒来或只醒来一次的人相比，夜间醒来两次或更多的人患MCI的几率更高（OR=2.6；95％CI=1.1-6.1）。在MCI患者中,睡眠不足与更好的一般认知功能和短期工作记忆有关，而在认知健康的老年人中,睡眠不足与情景记忆表现和执行功能受损有关.讨论：我们的结果证实了先前的研究，表明睡眠障碍在MCI中很常见，这可能是由于持续的神经退行性过程而不是认知障碍的症状。MCI需要进行客观睡眠测量的未来研究，以及改善睡眠以防止认知能力下降的干预措施。
