METHODS: Different errors were introduced in 33 error-free Head and Neck plans. The modified plans were recalculated using TPS software and the dose distributions obtained were compared to those of the original (error-free) plans. The comparison was performed using gamma analysis and the new method. The target was to calculate overall and organ-specific gamma passing rates as well as the overlapping ratio (OR) and volume ratio (VR) factors of the isodose structures method for each error-included plan.
RESULTS: Eight of the 33 plans passed both the gamma analysis and the isodose structures (IS) analysis, ten plans did not pass either of them, while 13 plans which did not pass the IS analysis, passed the gamma analysis. Two plans which did not pass gamma, passed IS analysis. Furthermore, Dose Volume Histogram (DVH) metrics could not detect the low agreement between the dose distributions of two error-free plans and the respective modified plans. In this case, the IS analysis also allowed us to detect clinically meaningful differences between measured and TPS dose distributions.
CONCLUSIONS: The IS method analysis clearly showed a high efficiency in detecting clinically relevant differences between TPS and measured dose distributions not seen in gamma analysis and in DVH-based metrics. Therefore, IS analysis proved to be a valid tool, alternative to gamma analysis for dose comparison in patient-specific QA test.